| Literature DB >> 4091991 |
A S Lewis, G Taylor, H O Williams, M H Lewis.
Abstract
Tobramycin concentrations have been determined in serum from capillary, venous and arterial blood samples taken from 16 patients during and after surgery. In 73 paired samples the concentrations in capillary samples were not significantly different from those measured in venous samples. The small concentration differences were neither dependent upon sampling time nor core-peripheral temperature differences. In 26 paired samples, concentrations in capillary samples were not significantly different from those determined in arterial samples. We conclude that concentrations in capillary samples are precise and unbiased estimators of venous concentrations and may be used in the adjustment of tobramycin dosage regimens.Entities:
Mesh：
Substances：
Year: 1985 PMID： 4091991 PMCID： PMC1400834 DOI： 10.1111/j.1365-2125.1985.tb05117.x
Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335