Literature DB >> 4090992

Oxotremorine acts as a partial nicotinic agonist on cultured chick myotubes.

J Häggblad, H Eriksson, E Heilbronn.   

Abstract

Oxotremorine, a compound widely used as a muscarinic agonist, was found to inhibit binding of 125I-alpha-bungarotoxin to chick myotube nicotinic acetylcholine receptors, IC50 = 79 +/- 5 microM. Oxotremorine also induced a d-tubocurarine sensitive influx of 86Rb in the myotubes (EC50 = 50 +/- 15 microM). Comparative ion-flux studies with carbachol suggested a partial agonist mode of action of oxotremorine.

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Year:  1985        PMID： 4090992     DOI： 10.1111/j.1600-0773.1985.tb00051.x

Source DB:  PubMed          Journal:  Acta Pharmacol Toxicol (Copenh)        ISSN： 0001-6683


  4 in total

1.  Forskolin blocks carbachol-mediated ion-permeability of chick myotube nicotinic receptors and inhibits binding of 3H-phencyclidine to Torpedo microsac nicotinic receptors.

Authors:  J Häggblad; H Eriksson; B Hedlund; E Heilbronn
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-10       Impact factor: 3.000

2.  Deprivation of Na+, Ca2+ and Mg2+ from the extracellular solution increases cytosolic Ca2+ and stimulates catecholamine secretion from cultured bovine adrenal chromaffin cells.

Authors:  M Luxoro; V Nassar-Gentina; E Rojas
Journal:  Mol Cell Biochem       Date:  1997-05       Impact factor: 3.396

3.  Muscarine receptors on the rat phrenic nerve, evidence for positive and negative muscarinic feedback mechanisms.

Authors:  I Wessler; M Karl; M Mai; A Diener
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-06       Impact factor: 3.000

4.  Both presynaptic nicotinic-like and muscarinic-like autoreceptors regulate acetylcholine release at an identified neuro-neuronal synapse of Aplysia.

Authors:  P Fossier; B Poulain; G Baux; L Tauc
Journal:  Pflugers Arch       Date:  1988-04       Impact factor: 3.657
  4 in total

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