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Literature DB >> 408862

Probenecid in CSF and plasma of rabbits and dogs measured by radioimmunoassay.

W L Shei, J Y Mu, R F Cunningham, Z H Israili, P G Dayton.

Abstract

Probenecid (P) in CSF of rabbits and dogs was investigated using a new radioimmunoassay technique. In rabbits, under steady-state conditions, CSF/free plasma concentration ratios of P were found to be similar to those reported in man. The ratios were concentration dependent and less than 0.5 suggesting an inhibition of transport of the drug in CNS. Under nonsteady-state conditions, no clear evidence of a transport system was found in dogs.

Entities: Chemical Species

Mesh：

Substances：
Probenecid

Year: 1977 PMID： 408862 DOI： 10.1007/bf00492371

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

25 in total

1. Active transport of Diodrast and phenolsulfonphthalein from cerebrospinal fluid to blood.

Authors: J R PAPPENHEIMER; S R HEISEY; E F JORDAN
Journal: Am J Physiol Date: 1961-01

2. The importance of dissociaton constant and lipid-solubility in influencing the passage of drugs into the cerebrospinal fluid.

Authors: B B BRODIE; H KURZ; L S SCHANKER
Journal: J Pharmacol Exp Ther Date: 1960-09 Impact factor: 4.030

3. Factors basic to the development of useful inhibitors of renal transport mechanisms.

Authors: K H BEYER
Journal: Arch Int Pharmacodyn Ther Date: 1954-05-01

4. 5-hydroxyindoleacetic acid and homovanillic acid in cerebrospinal fluid and brain of different rabbit breeds after treatment with probenecid.

Authors: H Andersson; B E Roos
Journal: J Pharm Pharmacol Date: 1972-02 Impact factor: 3.765

10. Probenecid: dosage, levels in plasma and cerebrospinal fluid (CSF) and influence upon CSF levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the rabbit.

Authors: J P Muizelaar; J I Oberink
Journal: Psychopharmacologia Date: 1975-09-17

1 in total

Review 1. Clinical pharmacokinetics of probenecid.

Authors: R F Cunningham; Z H Israili; P G Dayton
Journal: Clin Pharmacokinet Date: 1981 Mar-Apr Impact factor: 6.447

1 in total

Probenecid in CSF and plasma of rabbits and dogs measured by radioimmunoassay.

1. Active transport of Diodrast and phenolsulfonphthalein from cerebrospinal fluid to blood.

2. The importance of dissociaton constant and lipid-solubility in influencing the passage of drugs into the cerebrospinal fluid.

3. Factors basic to the development of useful inhibitors of renal transport mechanisms.

4. 5-hydroxyindoleacetic acid and homovanillic acid in cerebrospinal fluid and brain of different rabbit breeds after treatment with probenecid.

5. Lipid solubility and drug penetration of the blood brain barrier.

6. Impairment of hepatic uptake of rifamycin antibiotics by probenecid, and its therapeutic implications.

7. Determination of probenecid in small volumes of cerebrospinal fluid.

8. Transport of methotrexate by the choroid plexus.

9. Studies of the specificity of an antibody directed against probenecid. Investigations with probenecid analogs.

10. Probenecid: dosage, levels in plasma and cerebrospinal fluid (CSF) and influence upon CSF levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the rabbit.

Review 1. Clinical pharmacokinetics of probenecid.