Literature DB >> 408853

Effect of di-n-propylacetate on the 'binding of GABA to synaptosome-enriched fraction of rat cerebral cortex.

B M Kulig, C Gonzalez-Portal, E Somoza, F V Defeudis.   

Abstract

The effect of di-n-propylacetate (DPA) on the 'binding' of gamma-aminobutyric acid (GABA) to a synaptosome-enriched fraction of rat cerebral cortex has been examined using differential centrifugation and double-isotope liquid scintillation spectrometry. DPA at 10(-4) M caused a slight decrease in GABA binding. This effect could explain in part the in vivo anticonvulsant and behavioral effects of this drug when administered to animals in high systemic doses.

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Year:  1977        PMID： 408853     DOI： 10.1007/bf00492360

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  20 in total

1.  Regional distribution in brain and effect on cerebral mitochondrial respiration of the anticonvulsive drug n-dipropylacetate.

Authors:  L Ciesielski; M Maitre; C Cash; P Mandel
Journal:  Biochem Pharmacol       Date:  1975-05-01       Impact factor: 5.858

2.  [Pharmacodynamic properties of N-dipropylacetic acid].

Authors:  H MEUNIER; G CARRAZ; Y NEUNIER; P EYMARD; M AIMARD
Journal:  Therapie       Date:  1963 Mar-Apr       Impact factor: 2.070

3.  Binding of gamma-aminobutyric acid by brain preparations.

Authors:  K SANO; E ROBERTS
Journal:  Biochem Biophys Res Commun       Date:  1961-04-07       Impact factor: 3.575

4.  Effects of anticonvulsant drugs on the cerebral enzymes metabolizing GABA.

Authors:  M C Sawaya; R W Horton; B S Meldrum
Journal:  Epilepsia       Date:  1975-11       Impact factor: 5.864

5.  Comparison of the 'binding' of beta-alanine and gamma-aminobutyric acid in synaptosomal-mitochondrial fractions of rat brain.

Authors:  E Somoza; M P Pugnaire; L M Muñoz; C G Portal; A E Ibañez; F V DeFeudis
Journal:  J Neurochem       Date:  1977-06       Impact factor: 5.372

6.  Effect of sodium n-dipropylacetate on audiogenic seizures and brain -aminobutyric acid level.

Authors:  S Simler; L Ciesielski; M Maitre; H Randrianarisoa; P Mandel
Journal:  Biochem Pharmacol       Date:  1973-07-15       Impact factor: 5.858

7.  Studies on the content and metabolism of L-glutamate in peripheral nerve in vitro.

Authors:  F V DeFeudis
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1971-03

8.  The effects of n-dipropylacetate on the acquisition of conditioned behaviour with negative reinforcement in mice.

Authors:  R Misslin; P Ropartz; P Mandel
Journal:  Psychopharmacologia       Date:  1975-11-21

9.  Clinical trials of anti-epileptic drugs.

Authors:  H Meinardi
Journal:  Psychiatr Neurol Neurochir       Date:  1971 Mar-Apr

10.  Acute functional tolerance to the motor impairment effects of di-n-propylacetate.

Authors:  B M Kulig
Journal:  Pharmacol Biochem Behav       Date:  1976-11       Impact factor: 3.533
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