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Literature DB >> 40872

Human platelet arylsulphatases: identification and capacity to destroy SRS-A.

Abstract

Arylsulphatases IIA and IIB have been separately identified in human platelets by use of anion exchange chromatography and gel filtration. Arylsulphatase IIA had a molecular weight of 160,000 and a pH optimum of 4.5. Arylsulphatase IIB had a molecular weight of 60,000 and a pH optimum of 5.5. Both arylsulphatases IIA and IIB were inhibited by phosphate and sulphate ions characteristic of this enzyme class. Platelets, upon exposure to ionophore A-23187 or thrombin, discharged arylsulphatase coincident with beta-glcuronidase release. Partially purified platelet arylsulphatase IIB inactivated rat SRS-A.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1979 PMID： 40872 PMCID： PMC1457150

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

22 in total

1. Fine structural localization of arylsulfatase B activity in the rabbit blood platelets.

Authors: F Murata; T Nagata; S S Spicer
Journal: Histochemistry Date: 1975-09-29

2. The synthesis and hydrolysis of sulfate esters.

Authors: A B ROY
Journal: Adv Enzymol Relat Subj Biochem Date: 1960

3. The release of histamine and formation of a slow-reacting substance (SRS-A) during anaphylactic shock.

Authors: W E BROCKLEHURST
Journal: J Physiol Date: 1960-06 Impact factor: 5.182

4. Accumulation of platelets at sites of antigen-antibody-mediated injury: a possible role for IgE antibody and mast cells.

Authors: T C Kravis; P M Henson
Journal: J Immunol Date: 1977-05 Impact factor: 5.422

5. Identification and characterization of arylsulfatase A and B of the rat basophil leukemia tumor.

Authors: S I Wasserman; K F Austen
Journal: J Biol Chem Date: 1977-10-25 Impact factor: 5.157

6. Bronchial asthma: the possible role of the chemical mediators of immediate hypersensitivity in the pathogenesis of subacute chronic disease.

Authors: K F Austen; R P Orange
Journal: Am Rev Respir Dis Date: 1975-09

7. Arylsulfatase B of human lung. Isolation, characterization, and interaction with slow-reacting substance of anaphylaxis.

Authors: S I Wasserman; K F Austen
Journal: J Clin Invest Date: 1976-03 Impact factor: 14.808

Human platelet arylsulphatases: identification and capacity to destroy SRS-A.

1. Fine structural localization of arylsulfatase B activity in the rabbit blood platelets.

2. The synthesis and hydrolysis of sulfate esters.

3. The release of histamine and formation of a slow-reacting substance (SRS-A) during anaphylactic shock.

4. Accumulation of platelets at sites of antigen-antibody-mediated injury: a possible role for IgE antibody and mast cells.

5. Identification and characterization of arylsulfatase A and B of the rat basophil leukemia tumor.

6. Bronchial asthma: the possible role of the chemical mediators of immediate hypersensitivity in the pathogenesis of subacute chronic disease.

7. Arylsulfatase B of human lung. Isolation, characterization, and interaction with slow-reacting substance of anaphylaxis.

8. Inactivation of slow reacting substance of anaphylaxis by human eosinophil arylsulfatase.

9. Cytochemical localization of lysosomal enzymes in rat megakaryocytes and platelets.

10. Histaminase release from human eosinophils.

1. Arylsulfatase A activity and electrophoretic banding patterns from isolated human blood fractions.

2. Human Sulfotransferase Assays With PAPS Production in situ.