Literature DB >> 4084363

Subendothelial accumulation of unesterified cholesterol. An early event in atherosclerotic lesion development.

H S Kruth.   

Abstract

This preliminary report describes the simplest and possibly earliest lipid-containing lesions induced in aortas of rabbits fed a cholesterol-containing diet. Subendothelial accumulation of unesterified cholesterol, detected with filipin dye, appears to precede morphologic changes in endothelium and accumulation of subendothelial lipid-containing "foam" cells. The origin of subendothelial unesterified cholesterol remains to be determined.

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Year:  1985        PMID： 4084363     DOI： 10.1016/0021-9150(85)90045-0

Source DB:  PubMed          Journal:  Atherosclerosis        ISSN： 0021-9150            Impact factor:   5.162


  15 in total

1.  Macrophages create an acidic extracellular hydrolytic compartment to digest aggregated lipoproteins.

Authors:  Abigail S Haka; Inna Grosheva; Ethan Chiang; Adina R Buxbaum; Barbara A Baird; Lynda M Pierini; Frederick R Maxfield
Journal:  Mol Biol Cell       Date:  2009-10-07       Impact factor: 4.138

2.  Subendothelial retention of lipoprotein (a). Evidence that reduced heparan sulfate promotes lipoprotein binding to subendothelial matrix.

Authors:  S Pillarisetti; L Paka; J C Obunike; L Berglund; I J Goldberg
Journal:  J Clin Invest       Date:  1997-08-15       Impact factor: 14.808

3.  Unesterified cholesterol-rich lipid particles in atherosclerotic lesions of human and rabbit aortas.

Authors:  F F Chao; L M Amende; E J Blanchette-Mackie; S I Skarlatos; W Gamble; J H Resau; W T Mergner; H S Kruth
Journal:  Am J Pathol       Date:  1988-04       Impact factor: 4.307

4.  Transcriptomic Analysis of THP-1 Macrophages Exposed to Lipoprotein Hydrolysis Products Generated by Lipoprotein Lipase.

Authors:  Narmadaa Thyagarajan; Jenika D Marshall; Arthur T Pickett; Clemens Schumacher; Yanbo Yang; Sherri L Christian; Robert J Brown
Journal:  Lipids       Date:  2017-02-15       Impact factor: 1.880

5.  Lipolytic surface remnants of triglyceride-rich lipoproteins are cytotoxic to macrophages but not in the presence of high density lipoprotein. A possible mechanism of atherogenesis?

Authors:  B H Chung; J P Segrest; K Smith; F M Griffin; C G Brouillette
Journal:  J Clin Invest       Date:  1989-04       Impact factor: 14.808

6.  Characterization of two unique cholesterol-rich lipid particles isolated from human atherosclerotic lesions.

Authors:  F F Chao; E J Blanchette-Mackie; Y J Chen; B F Dickens; E Berlin; L M Amende; S I Skarlatos; W Gamble; J H Resau; W T Mergner
Journal:  Am J Pathol       Date:  1990-01       Impact factor: 4.307

7.  Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis.

Authors:  Bo Feng; Dajun Zhang; George Kuriakose; Cecillia M Devlin; Mark Kockx; Ira Tabas
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-15       Impact factor: 11.205

8.  Influence of chronic treatment with a nitric oxide donor on fatty streak development and reactivity of the rabbit aorta.

Authors:  H Bult; G R De Meyer; A G Herman
Journal:  Br J Pharmacol       Date:  1995-04       Impact factor: 8.739

Review 9.  Aggregation and fusion of low-density lipoproteins in vivo and in vitro.

Authors:  Mengxiao Lu; Olga Gursky
Journal:  Biomol Concepts       Date:  2013-10

10.  Early extracellular and cellular lipid deposits in aorta of cholesterol-fed rabbits.

Authors:  J R Guyton; K F Klemp
Journal:  Am J Pathol       Date:  1992-10       Impact factor: 4.307
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