| Literature DB >> 4084237 |
F Sinigaglia, C L Balduini, A Bisio, C Balduini.
Abstract
Thrombin treated with phenylmethanesulphonyl fluoride, like active enzyme, promotes modifications to human platelet cytoskeleton. The removal of active thrombin by hirudin partially reverses this process. Chymotrypsin-treated platelets do not modify their cytoskeleton after thrombin stimulus, but are still able to increase their adhesiveness to collagen. It is concluded that thrombin influences the cytoskeleton and adhesion by non-enzymic mechanisms which may be mediated by different modulators.Entities:
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Year: 1985 PMID： 4084237 PMCID： PMC1152877 DOI： 10.1042/bj2320305
Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857