Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The inhibition of protein-lysine 6-oxidase by various lathyrogens. Evidence for two different mechanisms.

Literature DB >> 4084235

The inhibition of protein-lysine 6-oxidase by various lathyrogens. Evidence for two different mechanisms.

Abstract

Lathyrogens decrease collagen and elastin cross-linking by inhibiting lysine oxidase. The lathyrogens isoniazid and semicarbazide decrease liver pyridoxal phosphate and are teratogenic; all their effects are reversed by pyridoxal. beta-Aminopropionitrile, another lathyrogen, does not affect liver pyridoxal phosphate, and its lathyrogenic and teratogenic effects are not reversed by pyridoxal. Time courses of these effects differ greatly, suggesting enzyme inhibition by different mechanisms.

Entities: Chemical Gene

Mesh：

Substances：

Year: 1985 PMID： 4084235 PMCID： PMC1152874 DOI： 10.1042/bj2320293

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

21 in total

1. The effect of lathyrogenic compounds on the glycogen content of the chick embryo liver.

Authors: C I LEVENE
Journal: Br J Exp Pathol Date: 1962-12

2. Evidence for the role of vitamin C-6 as a cofactor of lysyl oxidase.

Authors: J C Murray; C I Levene
Journal: Biochem J Date: 1977-11-01 Impact factor: 3.857

3. Fluorometric determination of pyridoxal phosphate in enzymes.

Authors: E Adams
Journal: Methods Enzymol Date: 1979 Impact factor: 1.600

4. Copper and amine oxidases in connective tissue metabolism.

Authors: E D Harris; B L O'Dell
Journal: Adv Exp Med Biol Date: 1974 Impact factor: 2.622

5. Intermediate labile intermolecular crosslinks in collagen fibres.

Authors: A J Bailey
Journal: Biochim Biophys Acta Date: 1968-08-13

6. The cross-linking of collagen and elastin: enzymatic conversion of lysine in peptide linkage to alpha-aminoadipic-delta-semialdehyde (allysine) by an extract from bone.

Authors: S R Pinnell; G R Martin
Journal: Proc Natl Acad Sci U S A Date: 1968-10 Impact factor: 11.205

7. The effect of a vitamin B-6 antagonist, 4-deoxypyridoxine, on the cross-linking of collagen in the developing chick embryo.

Authors: T A Bird; C I Levene
Journal: Biochem J Date: 1983-03-15 Impact factor: 3.857

The inhibition of protein-lysine 6-oxidase by various lathyrogens. Evidence for two different mechanisms.

1. The effect of lathyrogenic compounds on the glycogen content of the chick embryo liver.

2. Evidence for the role of vitamin C-6 as a cofactor of lysyl oxidase.

3. Fluorometric determination of pyridoxal phosphate in enzymes.

4. Copper and amine oxidases in connective tissue metabolism.

5. Intermediate labile intermolecular crosslinks in collagen fibres.

6. The cross-linking of collagen and elastin: enzymatic conversion of lysine in peptide linkage to alpha-aminoadipic-delta-semialdehyde (allysine) by an extract from bone.

7. The effect of a vitamin B-6 antagonist, 4-deoxypyridoxine, on the cross-linking of collagen in the developing chick embryo.

8. Reaction of aortic lysyl oxidase with beta-aminopropionitrile.

9. Structural requirements for lathyrogenic agents.

10. The lathyrogenic effect of isonicotinic acid hydrazide (INAH) on the chick embryo and its reversal by pyridoxal.

Review 1. Tuberculosis in pregnancy and the puerperium.

2. Inhibition of chick embryo lysyl oxidase by various lathyrogens and the antagonistic effect of pyridoxal.

Review 3. Drug treatment for tuberculosis during pregnancy: safety considerations.

4. Lysyl oxidase activity and elastin/glycosaminoglycan interactions in growing chick and rat aortas.