| Literature DB >> 4084181 |
F Bergmann, I Lieblich, E Cohen, J R Ganchrow.
Abstract
The time course for the development of morphine tolerance, following prolonged sweet intake, was examined in randomly bred Sabra rats. Exposure to 3% glucose in 6 mM saccharin solution increased drinking by about three times as compared to rats supplied only with water. Suppression of the analgesic effect of morphine was already detectable after 24 h of intake and became progressively more marked within the next 5 weeks. These results support an active interaction between sweet consumption and endogenous opioids in randomly bred rats.Entities:
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Year: 1985 PMID： 4084181 DOI： 10.1016/s0163-1047(85)90616-8
Source DB: PubMed Journal: Behav Neural Biol ISSN： 0163-1047