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Literature DB >> 4083867

Cerebrospinal fluid penetration of moxalactam in ventriculostomy patients.

R J Creger, R I Cowan, H S Nearman, J L Blumer, W R Selman, L H Danziger.

Abstract

The cerebrospinal fluid penetration of moxalactam was simultaneously investigated in three patients with presumed bacterial meningitis. When ratios of simultaneously drawn ventriculostomy to serum moxalactam levels of 1, 2, 3, and 4 h were examined, the penetration ratios were 7.8 +/- 2.4, 11.2 +/- 1.3, 14.2 +/- 2.5, and 15.0 +/- 4.9%, respectively. These ratios were not statistically different from the penetration of moxalactam calculated by the area under the concentration-time curve technique (8.97 +/- 1.89%).

Entities: Chemical Disease Species

Mesh：

Substances：
Moxalactam

Year: 1985 PMID： 4083867 PMCID： PMC180342 DOI： 10.1128/AAC.28.6.839

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

18 in total

1. Non-traumatic gram-negative bacillary meningitis in the Detroit Medical Center, 1964-1974; (with special mention of cases due to Escherichia coli).

Authors: L R Crane; A M Lerner
Journal: Medicine (Baltimore) Date: 1978-05 Impact factor: 1.889

2. Comparative multiple-dose pharmacokinetics of cefotaxime, moxalactam, and ceftazidime.

Authors: R Lüthy; J Blaser; A Bonetti; H Simmen; R Wise; W Siegenthaler
Journal: Antimicrob Agents Chemother Date: 1981-11 Impact factor: 5.191

3. Diffusion of moxalactam into the cerebrospinal fluid in children with bacterial meningitis.

Authors: M C Thirumoorthi; J A Buckley; M K Aravind; R E Kauffman; A S Dajani
Journal: J Pediatr Date: 1981-12 Impact factor: 4.406

Review 4. Pharmacokinetics of tissue penetration of antibiotics.

Authors: T Bergan
Journal: Rev Infect Dis Date: 1981 Jan-Feb

5. Pharmacokinetics and bacteriologic efficacy of moxalactam, cefotaxime, cefoperazone, and rocephin in experimental bacterial meningitis.

Authors: U B Schaad; G H McCracken; C A Loock; M L Thomas
Journal: J Infect Dis Date: 1981-02 Impact factor: 5.226

Review 6. Past and current roles for cephalosporin antibiotics in treatment of meningitis. Emphasis on use in gram-negative bacillary meningitis.

Authors: S H Landesman; M L Corrado; P M Shah; M Armengaud; M Barza; C E Cherubin
Journal: Am J Med Date: 1981-10 Impact factor: 4.965

Cerebrospinal fluid penetration of moxalactam in ventriculostomy patients.

1. Non-traumatic gram-negative bacillary meningitis in the Detroit Medical Center, 1964-1974; (with special mention of cases due to Escherichia coli).

2. Comparative multiple-dose pharmacokinetics of cefotaxime, moxalactam, and ceftazidime.

3. Diffusion of moxalactam into the cerebrospinal fluid in children with bacterial meningitis.

Review 4. Pharmacokinetics of tissue penetration of antibiotics.

5. Pharmacokinetics and bacteriologic efficacy of moxalactam, cefotaxime, cefoperazone, and rocephin in experimental bacterial meningitis.

Review 6. Past and current roles for cephalosporin antibiotics in treatment of meningitis. Emphasis on use in gram-negative bacillary meningitis.

7. Pharmacokinetics and cerebrospinal fluid penetration of moxalactam in children with bacterial meningitis.

8. Sequential ventricular fluid concentrations of ceftazidime--report of three cases.

9. Clinical evaluation of a new broad-spectrum oxa-beta-lactam antibiotic, moxalactam, in neonates and infants.

10. Successful treatment of gram-negative bacillary meningitis with moxalactam.

1. Penetration of cefuroxime into ventricular fluid in cerebrospinal fluid shunt infections.