| Literature DB >> 4082206 |
T Nishikawa, H J Bruyere, Y Takagi, E F Gilbert, H Uno.
Abstract
The cardiovascular teratogenicity and embryotoxicity of ephedrine was studied in chick embryos treated after 2.5-6 days of incubation (Hamburger-Hamilton developmental stages 17-28). The embryos were examined on day 14. Cardiovascular malformations were observed in 29% (29/101) of treated embryos. Complicated anomalies, such as double-outlet right ventricle (DORV), truncus arteriosus communis (TAC) or overriding aorta with ventricular septal defect (VSD) were seen frequently in embryos exposed to the agent on day 3 of incubation. Malformations were induced by ephedrine at a dose as low as 1 mumol/egg.Entities:
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Year: 1985 PMID： 4082206
Source DB: PubMed Journal: Toxicol Lett ISSN： 0378-4274 Impact factor: 4.372