Literature DB >> 4082126

On the isolation of the thrombin inhibitor hirudin.

P Walsmann, F Markwardt.   

Abstract

A procedure for isolation of hirudin from crude preparations was described. By the use of ion exchange chromatography and affinity chromatography preparations were obtained with a specific activity of 10 to 15 antithrombin units/micrograms. Separation into several fractions with the same activity suggests the existence of isoinhibitors.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 4082126     DOI： 10.1016/0049-3848(85)90293-2

Source DB:  PubMed          Journal:  Thromb Res        ISSN： 0049-3848            Impact factor:   3.944


  3 in total

1.  Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor.

Authors:  J L Richardson; B Kröger; W Hoeffken; J E Sadler; P Pereira; R Huber; W Bode; P Fuentes-Prior
Journal:  EMBO J       Date:  2000-11-01       Impact factor: 11.598

2.  In Vitro Antithrombotic, Hematological Toxicity, and Inhibitor Studies of Protocatechuic, Isovanillic, and p-Hydroxybenzoic Acids from Maclura tricuspidata (Carr.) Bur.

Authors:  Jun-Hui Choi; Seung Kim
Journal:  Molecules       Date:  2022-05-29       Impact factor: 4.927

Review 3.  Leech therapeutic applications.

Authors:  A M Abdualkader; A M Ghawi; M Alaama; M Awang; A Merzouk
Journal:  Indian J Pharm Sci       Date:  2013-03       Impact factor: 0.975
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.