Literature DB >> 4080257

Reduced activity of locus coeruleus neurons in hypertensive rats.

H R Olpe, K Berecek, R S Jones, M W Steinmann, C Sonnenburg, K G Hofbauer.   

Abstract

The influence of blood pressure on locus coeruleus (LC) neuronal activity was investigated in chloral hydrate anesthetized rats. Mean spontaneous firing rate of LC neurons was reduced by 25% in deoxycorticosterone acetate (DOCA-salt) treated Sprague-Dawley rats and by 19% in spontaneously hypertensive rats (SHR) as compared to their corresponding control animals. In acute experiments performed on normotensive rats, peripherally induced blood pressure changes elicited reciprocal changes in cell firing of the majority of LC neurons. The findings suggest that LC may have a role in long-term regulation of blood pressure.

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Year:  1985        PMID： 4080257     DOI： 10.1016/0304-3940(85)90395-7

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  6 in total

1.  Locus coeruleus neurons show reduced alpha 2-receptor responsiveness and decreased basal activity in spontaneously hypertensive rats.

Authors:  G Engberg; L Oreland; P Thorén; T Svensson
Journal:  J Neural Transm       Date:  1987       Impact factor: 3.575

2.  Enhanced assymetrical noradrenergic transmission in the olfactory bulb of deoxycorticosterone acetate-salt hypertensive rats.

Authors:  Tamara Abramoff; María J Guil; Vanina P Morales; Sandra I Hope; Celeste Soria; Liliana G Bianciotti; Marcelo S Vatta
Journal:  Neurochem Res       Date:  2013-07-26       Impact factor: 3.996

3.  A comparative autoradiographic study of the density of [3H]SR95531, [3H]MK-801 and [3H]cGMP binding in the locus coeruleus and central pontine grey of spontaneously hypertensive and Wistar-Kyoto rats.

Authors:  Song T Yao; Andrew J Lawrence
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2005-06-04       Impact factor: 3.000

4.  Purinergic modulation of cardiovascular function in the rat locus coeruleus.

Authors:  Song T Yao; Andrew J Lawrence
Journal:  Br J Pharmacol       Date:  2005-06       Impact factor: 8.739

5.  Inhibition of catecholamine (noradrenaline, dopamine) release in the locus coeruleus and the hypothalamus by baroreceptor activation: identification of the involved baroreceptors.

Authors:  C Schneider; N Singewald; A Philippu
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-09       Impact factor: 3.000

6.  Catecholamine release in the locus coeruleus is modified by experimentally induced changes in haemodynamics.

Authors:  N Singewald; A Philippu
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-01       Impact factor: 3.000
  6 in total

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