[Apolipoproteins and lipoproteins with differing physical activity and performance capability].

In 216 healthy subjects (74 endurance trained persons, 87 variably trained subjects and 55 sedentary individuals) the behaviour of triglycerides, total cholesterol, lipoproteins and apolipoproteins in blood serum - all in relation to physical performance capacity - were determined in the early morning under fasting conditions. HDL-/total cholesterol (%) as well as the ratios LDL/HDL and Apo A1/Apo A2 proved to have the highest selectivity. Only marginal differences or none at all between the groups were found for Apo B, Apo A2 and total cholesterol. In an analysis of correlation the strongest relation with physical performance was found for HDL-/total cholesterol (%), Apo A1/Apo A2, Apo A1 and LDL/HDL. No significant correlations were found for total-cholesterol, Apo B and Apo A2. When the influence of age and body weight was excluded in an analysis of partial correlation Apo A1 showed the strongest relation to physical performance. The relevant partial correlations for Apo A1/Apo A2, HDL-cholesterol and HDL-/total cholesterol (%) were found to be weaker. With regard to the influence of increased physical activity on the human lipid metabolism it was concluded that the determination of lipoproteins can be significantly supplemented by the determination of apolipoproteins. The behaviour of Apo A1 and Apo A1/Apo A2 indicates that enhanced physical activity increases the vasoprotective HDL2 subfraction.