| Literature DB >> 4078709 |
Y H Kao, C Y Yang, R R Chen, J D Huang.
Abstract
The pharmacokinetics of 5-fluorouracil (5-FU) was investigated in tumor-free anesthetized rats. Blood samples in the carotid artery and in the right atrium were sampled by cannulation during the steady-state infusion of 5-FU. Serum and blood samples were assayed by HPLC. After comparing the steady-state concentration of 5-FU in the right carotid artery with that in the right atrium, it was concluded that there was no pulmonary elimination of 5-FU in the anesthetized rat.Entities:
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Year: 1985 PMID： 4078709 DOI： 10.1002/jps.2600741016
Source DB: PubMed Journal: J Pharm Sci ISSN： 0022-3549 Impact factor: 3.534