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Literature DB >> 4077921

Experiences with the human tumor colony-forming assay in gynecologic malignancies.

G E Umbach, J Poethen, H von Matthiessen, H G Bender, U Koldovsky.

Abstract

Tumor samples from 74 patients with gynecologic malignancies including breast cancer were processed in a soft agar colony-forming assay. None of the samples resulted in a pure single cell suspension. Of the 10 samples meeting our criteria of evaluability for chemosensitivity testing, only 5 samples showed in vitro sensitivity to any drug. Of the 3 evaluable correlations between in vitro and in vivo results, 2 were correct. Due to the low rate of evaluable samples the assay has only limited value in the assignment of chemotherapeutic drugs for patients treated at our institution.

Entities: Disease Species

Mesh：

Substances：
Antineoplastic Agents

Year: 1985 PMID： 4077921 DOI： 10.1007/BF00399280

Source DB: PubMed Journal: J Cancer Res Clin Oncol ISSN： 0171-5216 Impact factor: 4.553

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References

18 in total

10. Comparison of drug sensitivity among tumor cells within a tumor, between primary tumor and metastases, and between different metastases in the human tumor colony-forming assay.

Authors: N Tanigawa; Y Mizuno; T Hashimura; K Honda; K Satomura; Y Hikasa; O Niwa; T Sugahara; O Yoshida; D H Kern
Journal: Cancer Res Date: 1984-06 Impact factor: 12.701

Experiences with the human tumor colony-forming assay in gynecologic malignancies.

1. "Clumpogenic" v clonogenic assay.

2. In vitro growth of human malignancies in a cloning assay.

3. Clinical correlations of leukemic clonogenic cell chemosensitivity assessed by in vitro continuous exposure to drugs.

4. Effects of clumps and clusters on survival measurements with clonogenic assays.

5. Human tumor colony assay and chemosensitivity testing.

6. Prospective clinical trial of a human tumor cloning system.

7. Clinical application of the clonogenic assay.

8. Soft agar colony formation assay for in vitro testing of sensitivity to chemotherapy of gynecologic malignancies.

9. Cooperative evaluation of human tumor chemosensitivity in the soft-agar assay and its clinical correlations.

10. Comparison of drug sensitivity among tumor cells within a tumor, between primary tumor and metastases, and between different metastases in the human tumor colony-forming assay.