Literature DB >> 4077341

The clearance of gentamicin from antibiotic-loaded bone cement.

S Downes, A E Brown, S Mukherjee.   

Abstract

The concentrations of Gentamicin in the serum, drainage fluid and urine were determined by radioimmunoassay in 40 patients after total hip replacement and 10 after knee replacement. Palacos R bone cement with added Gentamicin had been used to fix the prostheses in all cases. Two types of response were observed; in Group I the Gentamicin levels rose very rapidly, whereas in Group II a more gradual increase was seen. In all cases the level of Gentamicin had fallen to a negligible amount by the fifth day after operation.

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Year:  1985        PMID: 4077341     DOI: 10.1007/BF00268172

Source DB:  PubMed          Journal:  Int Orthop        ISSN: 0341-2695            Impact factor:   3.075


  2 in total

1.  Comparative study of gentamicin release from normal and low viscosity acrylic bone cement.

Authors:  L Bunetel; A Segui; M Cormier; F Langlais
Journal:  Clin Pharmacokinet       Date:  1990-10       Impact factor: 6.447

Review 2.  Current Concepts on the Application, Pharmacokinetics and Complications of Antibiotic-Loaded Cement Spacers in the Treatment of Prosthetic Joint Infections.

Authors:  Panagiotis V Samelis; Eftychios Papagrigorakis; Eleni Sameli; Andreas Mavrogenis; Olga Savvidou; Panagiotis Koulouvaris
Journal:  Cureus       Date:  2022-01-05
  2 in total

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