Literature DB >> 4077281

1-hydroxypyrene in human urine after exposure to coal tar and a coal tar derived product.

F J Jongeneelen, R B Anzion, C M Leijdekkers, R P Bos, P T Henderson.   

Abstract

A method for isolating 1-hydroxypyrene from urine is described. The presence of 1-hydroxypyrene in urine was identified by fluorescence excitation and emission scanning after HPLC-separation. 1-Hydroxypyrene could be detected in the urine of rats following oral administration of as little as 0.5 microgram pyrene. The dose-dependence of 1-hydroxypyrene in urine was evident after a wide range of pyrene dosing. After therapeutical coal tar treatment of dermatological patients the enhanced excretion of 1-hydroxypyrene was highly significant. Employees of a creosote impregnating plant showed an excretion pattern of 1-hydroxypyrene which could be related to their work. 1-Hydroxypyrene in urine of non-exposed people was very low, but detectable. It is suggested that the method reported is suitable for the assessment of uptake of man to pyrene, a compound that is commonly present in work environments which are associated with pollution of polycyclic aromatic hydrocarbons.

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Year:  1985        PMID： 4077281     DOI： 10.1007/BF00383545

Source DB:  PubMed          Journal:  Int Arch Occup Environ Health        ISSN： 0340-0131            Impact factor:   3.015


  10 in total

1.  Metabolism of polycyclic compounds. 23. The metabolism of pyrene in rats and rabbits.

Authors:  E Boyland; P Sims
Journal:  Biochem J       Date:  1964-02       Impact factor: 3.857

2.  The presence of the mutagenic polycyclic aromatic hydrocarbons benzo[a]pyrene and benz[a]anthracene in creosote P1.

Authors:  R P Bos; J L Theuws; C M Leijdekkers; P T Henderson
Journal:  Mutat Res       Date:  1984-06       Impact factor: 2.433

3.  Genotoxic exposure of workers creosoting wood.

Authors:  R P Bos; C T Hulshof; J L Theuws; P T Henderson
Journal:  Br J Ind Med       Date:  1984-05

4.  Detection of occupational exposure to genotoxic agents with a urinary mutagen assay.

Authors:  D Kriebel; B Commoner; D Bollinger; A Bronsdon; J Gold; J Henry
Journal:  Mutat Res       Date:  1983-03       Impact factor: 2.433

5.  Detection of acridine in human urine after topical coal-tar treatment.

Authors:  M Cerníková; H Dubský; J Horácek
Journal:  J Chromatogr       Date:  1983-03-11

6.  Polynuclear aromatic compounds, Part 1, Chemical, environmental and experimental data.

Authors: 
Journal:  IARC Monogr Eval Carcinog Risk Chem Hum       Date:  1983-12

7.  Mutagenicity of urine from psoriatic patients undergoing treatment with coal tar and ultraviolet light.

Authors:  L A Wheeler; M D Saperstein; N J Lowe
Journal:  J Invest Dermatol       Date:  1981-08       Impact factor: 8.551

8.  Identification of 1-hydroxypyrene as a major metabolite of pyrene in pig urine.

Authors:  S D Keimig; K W Kirby; D P Morgan; J E Keiser; T D Hubert
Journal:  Xenobiotica       Date:  1983-07       Impact factor: 1.908

9.  Excretion of 3-hydroxy-benzo(a)pyrene and mutagenicity in rat urine after exposure to benzo(a)pyrene.

Authors:  F J Jongeneelen; C M Leijdekkers; R P Bos; J L Theuws; P T Henderson
Journal:  J Appl Toxicol       Date:  1985-10       Impact factor: 3.446

10.  Mutagenicity studies with urine concentrates from coke plant workers.

Authors:  M Møller; E Dybing
Journal:  Scand J Work Environ Health       Date:  1980-09       Impact factor: 5.024
  10 in total
  21 in total

1.  Cardiac autonomic dysfunction from occupational exposure to polycyclic aromatic hydrocarbons.

Authors:  Mi-Sun Lee; Shannon Magari; David C Christiani
Journal:  Occup Environ Med       Date:  2010-12-16       Impact factor: 4.402

2.  Dietary and inhalation exposure to polycyclic aromatic hydrocarbons and urinary excretion of monohydroxy metabolites--a controlled case study in Beijing, China.

Authors:  Yanyan Zhang; Junnan Ding; Guofeng Shen; Junjun Zhong; Chen Wang; Siye Wei; Chaoqi Chen; Yuanchen Chen; Yan Lu; Huizhong Shen; Wei Li; Ye Huang; Han Chen; Shu Su; Nan Lin; Xilong Wang; Wenxin Liu; Shu Tao
Journal:  Environ Pollut       Date:  2013-10-29       Impact factor: 8.071

Review 3.  Tobacco carcinogen metabolites and DNA adducts as biomarkers in head and neck cancer: potential screening tools and prognostic indicators.

Authors:  Samir S Khariwala; Dorothy Hatsukami; Stephen S Hecht
Journal:  Head Neck       Date:  2011-05-25       Impact factor: 3.147

4.  Biological exposure limit for occupational exposure to coal tar pitch volatiles at cokeovens.

Authors:  F J Jongeneelen
Journal:  Int Arch Occup Environ Health       Date:  1992       Impact factor: 3.015

5.  Occupational exposure to polycyclic aromatic hydrocarbons: relations between atmospheric mixtures, urinary metabolites and sampling times.

Authors:  Damien Barbeau; Simon Lutier; Vincent Bonneterre; Renaud Persoons; Marie Marques; Claire Herve; Anne Maitre
Journal:  Int Arch Occup Environ Health       Date:  2015-03-06       Impact factor: 3.015

6.  Hydroxypyrene in urine of football players after playing on artificial sports field with tire crumb infill.

Authors:  Joost G M van Rooij; Frans J Jongeneelen
Journal:  Int Arch Occup Environ Health       Date:  2009-09-25       Impact factor: 3.015

7.  Comparison of 1-hydroxypyrene exposure in the US population with that in occupational exposure studies.

Authors:  Wenlin Huang; James Grainger; Donald G Patterson; Wayman E Turner; Samuel P Caudill; Larry L Needham; James L Pirkle; Eric J Sampson
Journal:  Int Arch Occup Environ Health       Date:  2004-08-21       Impact factor: 3.015

8.  Exposure to polycyclic aromatic hydrocarbons in petrochemical industries by measurement of urinary 1-hydroxypyrene.

Authors:  P J Boogaard; N J van Sittert
Journal:  Occup Environ Med       Date:  1994-04       Impact factor: 4.402

9.  Association of exposure to polycyclic aromatic hydrocarbons (estimated from job category) with concentration of 1-hydroxypyrene glucuronide in urine from workers at a steel plant.

Authors:  D Kang; N Rothman; S H Cho; H S Lim; H J Kwon; S M Kim; B Schwartz; P T Strickland
Journal:  Occup Environ Med       Date:  1995-09       Impact factor: 4.402

10.  Urinary hydroxy-metabolites of naphthalene, phenanthrene and pyrene as markers of exposure to diesel exhaust.

Authors:  Leea Kuusimäki; Yrjö Peltonen; Pertti Mutanen; Kimmo Peltonen; Kirsti Savela
Journal:  Int Arch Occup Environ Health       Date:  2003-10-17       Impact factor: 3.015
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