Literature DB >> 4076323

Comparison of the pharmacokinetic profile of metaclazepam in old and young volunteers.

K H Molz, W Gielsdorf, J Rasper, H Jaeger, H J Hausleiter, G Achtert, P Philipp.   

Abstract

A single-centre, open, Phase I-study comparison of the pharmacokinetics of a single dose of metaclazepam 10 mg, a new 1,4-benzodiazepine has been done in 10 older and 20 younger volunteers. No important age-related effect was found on the kinetics of metaclazepam or its N-desmethyl derivative, the principal metabolite in man.

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Year:  1985        PMID： 4076323     DOI： 10.1007/BF00547431

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  12 in total

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Journal:  Psychopharmacol Bull       Date:  1983

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Journal:  Clin Pharmacol Ther       Date:  1979-07       Impact factor: 6.875

8.  The effects of age and liver disease on the disposition and elimination of diazepam in adult man.

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Journal:  J Clin Invest       Date:  1975-02       Impact factor: 14.808

9.  Human pharmacokinetics of nitrazepam: effect of age and diseases.

Authors:  L Kangas; E Iisalo; J Kanto; V Lehtinen; S Pynnönen; I Ruikka; J Salminen; M Sillanpää; E Syvälahti
Journal:  Eur J Clin Pharmacol       Date:  1979-04-17       Impact factor: 2.953

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Authors:  D J Greenblatt; M Divoll; J S Harmatz; R I Shader
Journal:  J Pharmacol Exp Ther       Date:  1980-10       Impact factor: 4.030
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  3 in total

Review 1.  Hepatic drug metabolism and aging.

Authors:  C Durnas; C M Loi; B J Cusack
Journal:  Clin Pharmacokinet       Date:  1990-11       Impact factor: 6.447

Review 2.  Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part II).

Authors:  D J Greenblatt; J S Harmatz; R I Shader
Journal:  Clin Pharmacokinet       Date:  1991-10       Impact factor: 6.447

3.  Pharmacokinetic profile of metaclazepam (Talis), a new 1.4-benzodiazepine. Influence of different dosage regimens on the pharmacokinetic profile of metaclazepam and its main metabolite under steady-state conditions.

Authors:  W Gielsdorf; K H Molz; H J Hausleiter; G Achtert; P Philipp
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1986 Jul-Sep       Impact factor: 2.441
  3 in total

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