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Literature DB >> 407598

Changes in morphine self-administration after brainstem lesions in rats.

Abstract

Rats were trained to bar press for intravenous infusions of morphine sulfate during 1-h daily test regions. Rates of morphine self-administration were reduced by bilateral lesions of the substantia nigra and enhanced by lesions of the medial raphe nucleus. Dose-response studies indicated that sensitivity to morphine's rewarding property was increased by substantia nigra lesions and decreased by medial raphe lesions. Lesions of the dorsal raphe nucleus and of the locus coeruleus had no effect on self-administration behavior. An interaction between ascending dopaminergic and serotonergic pathways appears to be involved in the mechanism of morphine reinforcement.

Entities: Chemical Species

Mesh：

Substances：
Morphine

Year: 1977 PMID： 407598 DOI： 10.1007/bf00439102

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

21 in total

1. Synaptic mechanisms in the substantia nigra.

Authors: A Dray; D W Straughan
Journal: J Pharm Pharmacol Date: 1976-04 Impact factor: 3.765

Review 2. The serotonergic system in the brain and its possible functional connections with other aminergic systems.

Authors: R Samanin; S Garattini
Journal: Life Sci Date: 1975-10-15 Impact factor: 5.037

3. Alterations of dopaminergic neurotransmission after chronic morphine treatment: pre- and postjunctional studies in striatal tissue.

Authors: A Bosse; K Kuschinsky
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1976-07 Impact factor: 3.000

4. Effects of morphine on striatal dopamine metabolism: possible mechanism of its opposite effect on locomotor activity in rats and mice.

Authors: K Kuschinsky; O Hornykiewicz
Journal: Eur J Pharmacol Date: 1974-04 Impact factor: 4.432

5. Changes in sensitivity to the rewarding property of morphine following lesions of the medial forebrain bundle or caudate nucleus in rats.

Authors: S D Glick
Journal: Arch Int Pharmacodyn Ther Date: 1974-12

3. Morphine history sensitizes postsynaptic GABA receptors on dorsal raphe serotonin neurons in a stress-induced relapse model in rats.

Authors: D R Staub; J W Lunden; A M Cathel; E L Dolben; L G Kirby
Journal: Psychoneuroendocrinology Date: 2011-11-01 Impact factor: 4.905

3 in total

Changes in morphine self-administration after brainstem lesions in rats.

1. Synaptic mechanisms in the substantia nigra.

Review 2. The serotonergic system in the brain and its possible functional connections with other aminergic systems.

3. Alterations of dopaminergic neurotransmission after chronic morphine treatment: pre- and postjunctional studies in striatal tissue.

4. Effects of morphine on striatal dopamine metabolism: possible mechanism of its opposite effect on locomotor activity in rats and mice.

5. Changes in sensitivity to the rewarding property of morphine following lesions of the medial forebrain bundle or caudate nucleus in rats.

6. Regional 5-hydroxytryptamine following selective midbrain raphe lesions in the rat.

Review 7. Self administration of and behavioral dependence on drugs.

8. The effect of surgical lesions to frontal cortex and substantia nigra on amphetamine responses in rats.

9. Behavioral studies following lesions of the mesolimbic and mesostriatal serotonergic pathways.

10. Dopaminergic and cholinergic influences on morphine self-administration in rats.

1. 5-HT3 antagonists reduce morphine self-administration in rats.

2. Changes in morphine self-administration after tel-diencephalic lesions in rats.

3. Morphine history sensitizes postsynaptic GABA receptors on dorsal raphe serotonin neurons in a stress-induced relapse model in rats.