Literature DB >> 4074650

Acute toxicity of methyl isocyanate: a preliminary study of the dose response for eye and other effects.

A G Salmon, M Kerr Muir, N Andersson.   

Abstract

Acute toxic effects of methyl isocyanate in the rat were determined for two hour exposures to concentrations in the range 11 ppm (very slight effect) to 65 ppm (lethality: pulmonary oedema). Changes in the eye, lungs, and behaviour were noted. Eye changes were confined to erosions of the corneal epithelium and were most severe at intermediate levels of exposure. A comparison was made of the effects noted in rats with reported effects on survivors of the Bhopal disaster. Urinary thiocyanate concentrations in exposed rats were found to be reduced relative to control values.

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Year:  1985        PMID： 4074650      PMCID： PMC1007582          DOI： 10.1136/oem.42.12.795

Source DB:  PubMed          Journal:  Br J Ind Med        ISSN： 0007-1072


  6 in total

1.  [ON THE TOXICITY OF METHYLISOCYANATE AND ITS QUANTITATIVE DEERMINATION IN THE AIR].

Authors:  G KIMMERLE; A EBEN
Journal:  Arch Toxikol       Date:  1964-05-27

2.  Range-finding toxicity data: List VII.

Authors:  H F Smyth; C P Carpenter; C S Weil; U C Pozzani; J A Striegel; J S Nycum
Journal:  Am Ind Hyg Assoc J       Date:  1969 Sep-Oct

3.  Bhopal disaster: eye follow-up and analytical chemistry.

Authors:  N Andersson; M Kerr Muir; A G Salmon; C J Wells; R B Brown; C J Purnell; P C Mittal; V Mehra
Journal:  Lancet       Date:  1985-03-30       Impact factor: 79.321

4.  Does acute toxicity testing tell us anything useful? Methyl isocyanate as a test case.

Authors:  A G Salmon
Journal:  Br J Ind Med       Date:  1985-09

5.  Bioassay for evaluating the potency of airborne sensory irritants and predicting acceptable levels of exposure in man.

Authors:  Y Alarie
Journal:  Food Cosmet Toxicol       Date:  1981-10

6.  Method for determining urinary thiocyanates by a modified method of Lundquist.

Authors:  J C Aubry; M Swysen; H Bastenier; A Heuse
Journal:  Arch Belg       Date:  1982
  6 in total
  11 in total

1.  Bright red blood of Bhopal victims: cyanide or MIC?

Authors:  A G Salmon
Journal:  Br J Ind Med       Date:  1986-07

2.  Exposure and response to methyl isocyanate: results of a community based survey in Bhopal.

Authors:  N Andersson; M Kerr Muir; V Mehra; A G Salmon
Journal:  Br J Ind Med       Date:  1988-07

3.  From Flixborough to Bhopal: is legislation enough?

Authors:  P J Baxter
Journal:  Br J Ind Med       Date:  1986-01

4.  Delayed eye and other consequences from exposure to methyl isocyanate: 93% follow up of exposed and unexposed cohorts in Bhopal.

Authors:  N Andersson; M K Ajwani; S Mahashabde; M K Tiwari; M K Muir; V Mehra; K Ashiru; C D Mackenzie
Journal:  Br J Ind Med       Date:  1990-08

5.  Determination of methyl isopropyl hydantoin from rat erythrocytes by gas-chromatography mass-spectrometry to determine methyl isocyanate dose following inhalation exposure.

Authors:  Brian A Logue; Zhiling Zhang; Erica Manandhar; Adam L Pay; Claire R Croutch; Eric Peters; William Sosna; Jacqueline S Rioux; Livia A Veress; Carl W White
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2018-07-05       Impact factor: 3.205

6.  Biological effects of short-term, high-concentration exposure to methyl isocyanate. III. Influence on gas exchange in the guinea pig lung.

Authors:  M R Fedde; D E Dodd; C M Troup; E H Fowler
Journal:  Environ Health Perspect       Date:  1987-06       Impact factor: 9.031

7.  Sensory and pulmonary irritation of methyl isocyanate in mice and pulmonary irritation and possible cyanidelike effects of methyl isocyanate in guinea pigs.

Authors:  Y Alarie; J S Ferguson; M F Stock; D A Weyel; M Schaper
Journal:  Environ Health Perspect       Date:  1987-06       Impact factor: 9.031

8.  Toxicity of inhaled methyl isocyanate in F344/N rats and B6C3F1 mice. I. Acute exposure and recovery studies.

Authors:  J R Bucher; B N Gupta; B Adkins; M Thompson; C W Jameson; J E Thigpen; B A Schwetz
Journal:  Environ Health Perspect       Date:  1987-06       Impact factor: 9.031

9.  Effect of methyl isocyanate (MIC) gas on the eyes of Fischer 344 rats.

Authors:  B N Gupta; S A Stefanski; J R Bucher; L B Hall
Journal:  Environ Health Perspect       Date:  1987-06       Impact factor: 9.031

10.  Respiratory tract changes in guinea pigs, rats, and mice following a single six-hour exposure to methyl isocyanate vapor.

Authors:  E H Fowler; D E Dodd
Journal:  Environ Health Perspect       Date:  1987-06       Impact factor: 9.031
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