Literature DB >> 4074621

Determinants of plasma alpha 1-acid glycoprotein (AAG) concentrations in health.

P G Blain, J C Mucklow, M D Rawlins, D F Roberts, P A Routledge, D G Shand.   

Abstract

The concentration of alpha 1-acid glycoprotein (AAG) was measured in plasma from 200 healthy subjects belonging to 78 family units. The AAG concentration varied markedly between individuals (mean 0.77, range 0.36-1.46 g 1(-1]. When the genetic contribution to the variability was assessed, the only significant correlation observed was that between husband and wife and this was weak. We conclude that in addition to the known effects of age and gender, environmental (rather than genetic) factors largely determine the variance of AAG concentrations.

Mesh:

Substances:

Year:  1985        PMID: 4074621      PMCID: PMC1400715          DOI: 10.1111/j.1365-2125.1985.tb05107.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN: 0306-5251            Impact factor:   4.335


  6 in total

1.  Normal values for 23 different human plasma proteins determined by single radial immunodiffusion.

Authors:  K Störiko
Journal:  Blut       Date:  1968-01

2.  Immunochemical quantitation of antigens by single radial immunodiffusion.

Authors:  G Mancini; A O Carbonara; J F Heremans
Journal:  Immunochemistry       Date:  1965-09

3.  Family study of antipyrine clearance.

Authors:  P G Blain; J C Mucklow; P Wood; D F Roberts; M D Rawlins
Journal:  Br Med J (Clin Res Ed)       Date:  1982-01-16

4.  Sex-related differences in the plasma protein binding of lignocaine and diazepam.

Authors:  P A Routledge; W W Stargel; B B Kitchell; A Barchowsky; D G Shand
Journal:  Br J Clin Pharmacol       Date:  1981-03       Impact factor: 4.335

5.  The influence of pregnancy and oral contraceptive steroids on the concentration of plasma proteins. Studies with a quantitative immunodiffusion method.

Authors:  C S Song; I R Merkatz; A B Rifkind; P N Gillette; A Kappas
Journal:  Am J Obstet Gynecol       Date:  1970-09-15       Impact factor: 8.661

6.  The effects of age and smoking on the plasma protein binding of lignocaine and diazepam.

Authors:  D Davis; S H Grossman; B B Kitchell; D G Shand; P A Routledge
Journal:  Br J Clin Pharmacol       Date:  1985-02       Impact factor: 4.335

  6 in total
  22 in total

1.  Influence of menstrual cycle phase on serum concentrations of alpha 1-acid glycoprotein.

Authors:  R C Parish; C Spivey
Journal:  Br J Clin Pharmacol       Date:  1991-02       Impact factor: 4.335

2.  The effect of age on serum concentrations of albumin and alpha 1-acid glycoprotein.

Authors:  B T Veering; A G Burm; J H Souverijn; J M Serree; J Spierdijk
Journal:  Br J Clin Pharmacol       Date:  1990-02       Impact factor: 4.335

3.  A predictive pharmacokinetic/pharmacodynamic model of fentanyl for analgesia/sedation in neonates based on a semi-physiologic approach.

Authors:  Esther Encinas; Rosario Calvo; John C Lukas; Valvanera Vozmediano; Monica Rodriguez; Elena Suarez
Journal:  Paediatr Drugs       Date:  2013-06       Impact factor: 3.022

4.  Repository Describing an Aging Population to Inform Physiologically Based Pharmacokinetic Models Considering Anatomical, Physiological, and Biological Age-Dependent Changes.

Authors:  Felix Stader; Marco Siccardi; Manuel Battegay; Hannah Kinvig; Melissa A Penny; Catia Marzolini
Journal:  Clin Pharmacokinet       Date:  2019-04       Impact factor: 6.447

5.  The plasma protein binding of basic drugs.

Authors:  P A Routledge
Journal:  Br J Clin Pharmacol       Date:  1986-11       Impact factor: 4.335

Review 6.  Plasma protein binding of drugs in the elderly.

Authors:  S M Wallace; R K Verbeeck
Journal:  Clin Pharmacokinet       Date:  1987-01       Impact factor: 6.447

7.  Data Sets Representative of the Structures and Experimental Properties of FDA-Approved Drugs.

Authors:  Dominique Douguet
Journal:  ACS Med Chem Lett       Date:  2018-01-29       Impact factor: 4.345

Review 8.  Serum sialylation changes in cancer.

Authors:  Zejian Zhang; Manfred Wuhrer; Stephanie Holst
Journal:  Glycoconj J       Date:  2018-04-21       Impact factor: 2.916

9.  Orosomucoid (ORM) typing by isoelectric focusing: evidence for gene duplication of ORM1 and genetic polymorphism of ORM2.

Authors:  I Yuasa; K Suenaga; K Umetsu; K Ito; M Robinet-Levy
Journal:  Hum Genet       Date:  1987-11       Impact factor: 4.132

10.  Gallopamil binding to human serum proteins.

Authors:  D R Rutledge; J A Pieper
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.