| Literature DB >> 4074609 |
P J Meffin, B C Sallustio, Y J Purdie, R A Robson, L M Wing, P M Brooks.
Abstract
The disposition of prednisolone has been studied in eight male subjects with and without the concomitant administration of cortisol which produced plasma cortisol concentrations 10-fold higher than endogenous levels. The clearance and steady-state distribution volume of total prednisolone were increased as was the prednisolone free fraction but the clearance of unbound prednisolone was unaltered by cortisol co-administration.Entities:
Mesh：
Substances：
Year: 1985 PMID： 4074609 PMCID： PMC1400879 DOI： 10.1111/j.1365-2125.1985.tb05087.x
Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335