Literature DB >> 4074413

Correlation of biliary epomediol-beta-glucuronide levels with bile flow enhancement in the rat.

P Ventura, B Lumachi, F Luzzani, R Scuri.   

Abstract

In female Wistar rats, epomediol (Clesidren) (30-300 mg/kg p.o.) induced a dose-dependent increase of bile flow and a concomitant enhancement in both unchanged drug and its mono-beta-glucuronide (M 3) biliary levels. Pretreatment with galactosamine (300 mg/kg i.p.) abolished the bile flow increase and resulted in a marked decrease of M 3 but not of the unchanged drug. Moreover, a highly significant correlation (r = 0.809) between M 3 biliary concentration and bile flow was found.

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Year:  1985        PMID： 4074413

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


  6 in total

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Journal:  Nat Plants       Date:  2021-01-04       Impact factor: 15.793

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Journal:  Front Pharmacol       Date:  2022-03-04       Impact factor: 5.810

5.  Distinct microbial communities among different tissues of citrus tree Citrus reticulata cv. Chachiensis.

Authors:  Yongxian Wu; Mengqiu Qu; Xinhua Pu; Jintian Lin; Benshui Shu
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6.  Host preference and invasiveness of commensal bacteria in the Lotus and Arabidopsis root microbiota.

Authors:  Kathrin Wippel; Ke Tao; Yulong Niu; Rafal Zgadzaj; Niklas Kiel; Rui Guan; Eik Dahms; Pengfan Zhang; Dorthe B Jensen; Elke Logemann; Simona Radutoiu; Paul Schulze-Lefert; Ruben Garrido-Oter
Journal:  Nat Microbiol       Date:  2021-07-26       Impact factor: 17.745
  6 in total

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