Literature DB >> 4071565

Pyruvate and related alpha-ketoacids protect mammalian cells in culture against hydrogen peroxide-induced cytotoxicity.

U Andrae, J Singh, K Ziegler-Skylakakis.   

Abstract

Pyruvate efficiently protected V79 Chinese hamster cells against the lethal effects of hydrogen peroxide. Protection was also provided by other alpha-ketoacids, such as alpha-ketobutyrate, alpha-ketoglutarate and alpha-ketoadipate, although higher concentrations were required. The corresponding beta-ketoacids had no effect. The results indicate that pyruvate and other alpha-ketoacids possess antioxidant activity in vitro and, probably, in vivo.

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Year:  1985        PMID： 4071565     DOI： 10.1016/0378-4274(85)90015-3

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  40 in total

1.  Long-term primary culture of highly-pure rat embryonic hippocampal neurons of low-density.

Authors:  Hao Yang; Rui Cong; Luo Na; Gong Ju; Si-Wei You
Journal:  Neurochem Res       Date:  2010-05-26       Impact factor: 3.996

2.  Alterations of cellular bioenergetics in pulmonary artery endothelial cells.

Authors:  Weiling Xu; Thomas Koeck; Abigail R Lara; Donald Neumann; Frank P DiFilippo; Michelle Koo; Allison J Janocha; Fares A Masri; Alejandro C Arroliga; Constance Jennings; Raed A Dweik; Rubin M Tuder; Dennis J Stuehr; Serpil C Erzurum
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-16       Impact factor: 11.205

3.  Neuroprotective Effect of Creatine and Pyruvate on Enzyme Activities of Phosphoryl Transfer Network and Oxidative Stress Alterations Caused by Leucine Administration in Wistar Rats.

Authors:  Elenara Rieger; Itiane Diehl de Franceschi; Thales Preissler; Clovis Milton Duval Wannmacher
Journal:  Neurotox Res       Date:  2017-06-13       Impact factor: 3.911

4.  Evaluation of Oxidative Stress Parameters and Energy Metabolism in Cerebral Cortex of Rats Subjected to Sarcosine Administration.

Authors:  Rodrigo Binkowski de Andrade; Tanise Gemelli; Denise Bertin Rojas; Tomas Duk Hwa Kim; Ângela Zanatta; Felipe Schmitz; André Felipe Rodrigues; Angela T S Wyse; Moacir Wajner; Carlos Severo Dutra-Filho; Clovis Milton Duval Wannmacher
Journal:  Mol Neurobiol       Date:  2016-06-29       Impact factor: 5.590

Review 5.  Oxidative stress and living cells.

Authors:  G Gille; K Sigler
Journal:  Folia Microbiol (Praha)       Date:  1995       Impact factor: 2.099

6.  Improving stable transfection efficiency: antioxidants dramatically improve the outgrowth of clones under dominant marker selection.

Authors:  M Brielmeier; J M Béchet; M H Falk; M Pawlita; A Polack; G W Bornkamm
Journal:  Nucleic Acids Res       Date:  1998-05-01       Impact factor: 16.971

7.  Neuroprotective profile of pyruvate against ethanol-induced neurodegeneration in developing mice brain.

Authors:  Najeeb Ullah; Muhammad Imran Naseer; Ikram Ullah; Tae Hyun Kim; Hae Young Lee; Myeong Ok Kim
Journal:  Neurol Sci       Date:  2013-03-15       Impact factor: 3.307

8.  Alpha-tocopherol is ineffective in preventing the decomposition of preformed lipid peroxides and may promote the accumulation of toxic aldehydes: a potential explanation for the failure of antioxidants to affect human atherosclerosis.

Authors:  Achuthan Raghavamenon; Mahdi Garelnabi; Sainath Babu; Alex Aldrich; Dmitry Litvinov; Sampath Parthasarathy
Journal:  Antioxid Redox Signal       Date:  2009-06       Impact factor: 8.401

9.  Creatine and pyruvate prevent the alterations caused by tyrosine on parameters of oxidative stress and enzyme activities of phosphoryltransfer network in cerebral cortex of Wistar rats.

Authors:  Rodrigo Binkowski de Andrade; Tanise Gemelli; Denise Bertin Rojas; Narielle Ferner Bonorino; Bruna May Lopes Costa; Cláudia Funchal; Carlos Severo Dutra-Filho; Clovis Milton Duval Wannmacher
Journal:  Mol Neurobiol       Date:  2014-06-25       Impact factor: 5.590

10.  Effect of pyruvate on rat heart thiol status during ischemia and hypoxia followed by reperfusion.

Authors:  M P Rigobello; A Bindoli
Journal:  Mol Cell Biochem       Date:  1993-05-26       Impact factor: 3.396
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