| Literature DB >> 407109 |
R B Gwatkin, D T Williams, D J Carlo.
Abstract
Immunization of female mice with heat-solubilized hamster zonae pellucidae resulted in the production of antibody specific for the zona pellucida of several species, including that of primates. Complete, although temporary, infertility was produced in the mice. The zonae of ovulated eggs from the immune mice were found to contain antibody and complement. Many also appeared abnormal, but no apparent effect was observed on either vitelli or any of the other tissues that were examined. These results suggest the feasibility of developing a zona vaccine for contraception.Entities:
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Year: 1977 PMID： 407109 DOI： 10.1016/s0015-0282(16)42744-5
Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329