| Literature DB >> 406997 |
S A Jacobs, R G Stoller, B A Chabner, D G Johns.
Abstract
Humans and rhesus monkeys receiving high-dose methotrexate (MTX) (greater than 50 mg/kg) excrete significant quantities of the metabolite, 7-hydroxy-MTX. This metabolite, though 200-fold less potent than MTX as an inhibitor of mammalian dihydrofolate reductase, is of very limited aqueous solubility, and thus may contribute to the renal toxicity of the high-dose regimen. The metabolite was not observed in previous pharmacologic studies in which conventional doses of MTX were administered (less than 10 mg/kg).Entities:
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Year: 1977 PMID： 406997
Source DB: PubMed Journal: Cancer Treat Rep ISSN： 0361-5960