The Port Pirie cohort study. Blood lead concentrations in early childhood.

A cohort of over 600 children who were born between 1979 and 1982 and accounted for the great majority of all births in Port Pirie, South Australia, and its immediate environs, underwent capillary blood sampling at the ages of 6 months, 15 months, 2 years, and annually thereafter. The mean blood lead concentration (Pb-B) initially rose markedly, peaked at 2 years of age, and subsequently declined gradually at 3 and 4 years of age. No differences in Pb-B were observed between girls and boys. Secular trends in Pb-B at the age of 2 years that were observed in blood samples taken over the 1981-1984 period suggest that both the drought of 1982 and changes in community behaviour may have accounted for some of the age-related variation. The Pb-B was associated positively with surface soil lead concentrations, with a two-fold variation in mean Pb-B between residential zones within Port Pirie. Pb-B was higher in summer than in winter months at the ages of 6 and 15 months, but not at older ages. These findings suggest that lead in dust influences strongly blood lead concentrations in early childhood.