Literature DB >> 4069032

The side effects of antimalarial drugs indicates a polyamine involvement in both schizophrenia and depression.

R C Andrews.   

Abstract

The nature of the side effects produced by the antimalarials and a common moiety present in these drugs (spermidine) links the polyamines to both schizophrenia and depression. The raised incidence of psychosis in systemic lupus erythematosus and during pregnancy both associated with raised blood polyamine levels, makes the involvement of the polyamines in psychosis more likely.

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Year:  1985        PMID: 4069032     DOI: 10.1016/0306-9877(85)90114-8

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN: 0306-9877            Impact factor:   1.538


  3 in total

1.  The effects of some polyamines on putative behavioural indices of mesolimbic versus striatal dopaminergic function.

Authors:  S R Hirsch; R Richardson-Andrews; B Costall; M E Kelly; J de Belleroche; R J Naylor
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

2.  Polyamine oxidase activity in sera of depressed and schizophrenic patients after ECT treatment.

Authors:  K A Dahel; N M Al-Saffar; K A Flayeh
Journal:  Neurochem Res       Date:  2001-04       Impact factor: 3.996

Review 3.  Implication of the polyamine system in mental disorders.

Authors:  Laura M Fiori; Gustavo Turecki
Journal:  J Psychiatry Neurosci       Date:  2008-03       Impact factor: 6.186

  3 in total

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