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Literature DB >> 406831

Inducible resistance to D-cycloserine in Bacillus subtilis 168.

Abstract

Resistance to d-cycloserine could be induced in Bacillus subtilis 168 by sublethal concentrations of d-cycloserine. Sensitivity to the antibiotic could be regained by growth in the absence of d-cycloserine. The bactericidal activity of d-cycloserine apparently was not altered by resistant cells, and peptidoglycan synthesis was still inhibited by d-cycloserine in resistant cells. The d-cycloserine resistance apparently resulted from a decreased uptake of the antibiotic. The decrease in d-cycloserine transport could be prevented by simultaneous treatment of the cells with rifampin and d-cycloserine. d-Cycloserine was transported by the same system as glycine in B. subtilis. d-Cycloserine was able to exchange for intracellular glycine in both sensitive and resistant cells, suggesting that d-cycloserine is not excluded from the cell in resistant cultures.

Entities: Chemical Species

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Year: 1977 PMID： 406831 PMCID： PMC352089 DOI： 10.1128/AAC.11.5.871

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

1. THE ENZYMATIC SYNTHESIS OF D-ALANYL-D-ALANINE. 3. ON THE INHIBITION OF D-ALANYL-D-ALANINE SYNTHETASE BY THE ANTIBIOTIC D-CYCLOSERINE.

Authors: F C NEUHAUS; J L LYNCH
Journal: Biochemistry Date: 1964-04 Impact factor: 3.162

2. A fractionation procedure for studies of the synthesis of cell-wall mucopeptide and of other polymers in cells of Staphylococcus aureus.

Authors: J T PARK; R HANCOCK
Journal: J Gen Microbiol Date: 1960-02

3. TRANSFORMATION OF BIOCHEMICALLY DEFICIENT STRAINS OF BACILLUS SUBTILIS BY DEOXYRIBONUCLEATE.

Authors: J Spizizen
Journal: Proc Natl Acad Sci U S A Date: 1958-10-15 Impact factor: 11.205

4. R-factor-mediated resistance to tetracycline in Escherichia coli K12: an R-factor with a mutation to temperature-sensitive tetracycline resistance.

Authors: T W Young; S J Hubball
Journal: Biochem Biophys Res Commun Date: 1976-05-03 Impact factor: 3.575

Inducible resistance to D-cycloserine in Bacillus subtilis 168.

1. THE ENZYMATIC SYNTHESIS OF D-ALANYL-D-ALANINE. 3. ON THE INHIBITION OF D-ALANYL-D-ALANINE SYNTHETASE BY THE ANTIBIOTIC D-CYCLOSERINE.

2. A fractionation procedure for studies of the synthesis of cell-wall mucopeptide and of other polymers in cells of Staphylococcus aureus.

3. TRANSFORMATION OF BIOCHEMICALLY DEFICIENT STRAINS OF BACILLUS SUBTILIS BY DEOXYRIBONUCLEATE.

4. R-factor-mediated resistance to tetracycline in Escherichia coli K12: an R-factor with a mutation to temperature-sensitive tetracycline resistance.

5. Synthesis of an R plasmid protein associated with tetracycline resistance is negatively regulated.

6. Enzymes that inactivate antibiotics in transit to their targets.

7. Mechanism of D-cycloserine action: alanine racemase from Escherichia coli W.

8. Isolation and characterization of tetracycline resistance proteins from Staphylococcus aureus and Escherichia coli.

9. Mechanism of D-cycloserine action: transport systems for D-alanine, D-cycloserine, L-alanine, and glycine.

10. Mechanism of D-cycloserine action: transport mutants for D-alanine, D-cycloserine, and glycine.

1. Requirement for peptidoglycan synthesis during sporulation of Bacillus subtilis.

2. The shared antibiotic resistome of soil bacteria and human pathogens.

3. D-Cycloserine-induced alterations in the transport of D-alanine and glycine in Bacillus subtilis 168.

4. Rates of peptidoglycan turnover and cell growth of Bacillus subtilis are correlated.