Literature DB >> 4068001

Synthesis, characterization, and anorectic testing of the four stereoisomers of cyclo(histidylproline).

M J Kukla, H J Breslin, C R Bowden.   

Abstract

All four possible stereoisomers of cyclo(histidylproline) were individually synthesized, purified, and characterized. They were each tested for anorectic activity in rats with a free feeding paradigm over 24 h. Contrary to literature reports, none significantly reduced food intake at any time over the test period.

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Year:  1985        PMID： 4068001     DOI： 10.1021/jm00149a035

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  4 in total

1.  Conformation for a beta-cyclodextrin monosubstituted with a cyclic dipeptide.

Authors:  B Di Blasio; V Pavone; F Nastri; C Isernia; M Saviano; C Pedone; V Cucinotta; G Impellizzeri; E Rizzarelli; G Vecchio
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-01       Impact factor: 11.205

2.  A Small Molecule Coordinates Symbiotic Behaviors in a Host Organ.

Authors:  Katherine E Zink; Denise A Ludvik; Phillip R Lazzara; Terry W Moore; Mark J Mandel; Laura M Sanchez
Journal:  mBio       Date:  2021-03-09       Impact factor: 7.867

3.  Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence.

Authors:  Alba Minelli; Carmela Conte; Silvia Grottelli; Ilaria Bellezza; Ivana Cacciatore; Juan P Bolaños
Journal:  J Cell Mol Med       Date:  2008-03-29       Impact factor: 5.310

4.  Histidyl-Proline Diketopiperazine Isomers as Multipotent Anti-Alzheimer Drug Candidates.

Authors:  Hasan Turkez; Ivana Cacciatore; Mehmet Enes Arslan; Erika Fornasari; Lisa Marinelli; Antonio Di Stefano; Adil Mardinoglu
Journal:  Biomolecules       Date:  2020-05-09
  4 in total

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