| Literature DB >> 4067998 |
J R McCarthy, D L Wright, A J Schuster, A H Abdallah, P J Shea, R Eyster.
Abstract
A number of N,N'-dialkylarylamidines were synthesized and evaluated for antidepressant activity. Several of these compounds were synthesized from the corresponding nitriles by a new method. Slight structural modification in the series caused a marked change in biological activity and led to compounds as active as imipramine. The arylacetamidine, N,N'-dimethyl-2-naphthaleneethanimidamide hydrochloride (33) (napactadine) was selected for clinical study. Forty-eight additional analogues of 33, including a number of N-alkylamidines, were prepared.Entities:
Mesh：
Substances：
Year: 1985 PMID： 4067998 DOI： 10.1021/jm00149a031
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446