Literature DB >> 4066124

The relationship of enzyme activity to feeding behavior in rats: lipoprotein lipase as the metabolic gatekeeper.

M R Greenwood.   

Abstract

A model for peripheral modulation of feeding behavior is discussed. This model proposes that under certain genetic, hormonal or dietary conditions adipose tissue lipoprotein lipase (AT-LPL) acts as a gatekeeper directing triglyceride derived fuels to adipose tissue and away from other tissues. It is proposed that shifts in the activity of the gatekeeper enzyme LPL result in changed feeding behaviors in rodents and possibly in man. In the fafa rat, the alterations in LPL activity may play the role of a developmental trigger or initiator. In other cases, the changes in AT-LPL may be adaptive rather than initiatory and may be permissive of behaviors rather than necessary antecedents.

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Year:  1985        PMID： 4066124

Source DB:  PubMed          Journal:  Int J Obes


  19 in total

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Review 2.  Effects of gut microbes on nutrient absorption and energy regulation.

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3.  Increasing adipocyte lipoprotein lipase improves glucose metabolism in high fat diet-induced obesity.

Authors:  R Grace Walton; Beibei Zhu; Resat Unal; Michael Spencer; Manjula Sunkara; Andrew J Morris; Richard Charnigo; Wendy S Katz; Alan Daugherty; Deborah A Howatt; Philip A Kern; Brian S Finlin
Journal:  J Biol Chem       Date:  2015-03-17       Impact factor: 5.157

4.  Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase.

Authors:  P H Weinstock; S Levak-Frank; L C Hudgins; H Radner; J M Friedman; R Zechner; J L Breslow
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-16       Impact factor: 11.205

5.  Effect of feeding and obesity on lipoprotein lipase activity, immunoreactive protein, and messenger RNA levels in human adipose tissue.

Authors:  J M Ong; P A Kern
Journal:  J Clin Invest       Date:  1989-07       Impact factor: 14.808

6.  Adipose-specific lipoprotein lipase deficiency more profoundly affects brown than white fat biology.

Authors:  Itsaso Garcia-Arcos; Yaeko Hiyama; Konstantinos Drosatos; Kalyani G Bharadwaj; Yunying Hu; Ni Huiping Son; Sheila M O'Byrne; Chuchun L Chang; Richard J Deckelbaum; Manabu Takahashi; Marit Westerterp; Joseph C Obunike; Hongfeng Jiang; Hiroaki Yagyu; William S Blaner; Ira J Goldberg
Journal:  J Biol Chem       Date:  2013-03-31       Impact factor: 5.157

7.  Minor allele of the APOA4 gene T347S polymorphism predisposes to obesity in postmenopausal Turkish women.

Authors:  Filiz Guclu-Geyik; Altan Onat; Neslihan Coban; Evrim Komurcu-Bayrak; Vedat Sansoy; Günay Can; Nihan Erginel-Unaltuna
Journal:  Mol Biol Rep       Date:  2012-10-25       Impact factor: 2.316

8.  Lipoprotein lipase expression exclusively in liver. A mouse model for metabolism in the neonatal period and during cachexia.

Authors:  M Merkel; P H Weinstock; T Chajek-Shaul; H Radner; B Yin; J L Breslow; I J Goldberg
Journal:  J Clin Invest       Date:  1998-09-01       Impact factor: 14.808

9.  Increased thermoregulation in cold-exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: an avian phenotype?

Authors:  Dalan R Jensen; Leslie A Knaub; John P Konhilas; Leslie A Leinwand; Paul S MacLean; Robert H Eckel
Journal:  J Lipid Res       Date:  2008-01-05       Impact factor: 5.922

10.  Myocardial metabolic regulation through peroxisome proliferator-activated receptor alpha after myocardial infarction.

Authors:  Katsuhiko Masamura; Nobuyoshi Tanaka; Masahiro Yoshida; Masayuki Kato; Yasuyuki Kawai; Koji Oida; Isamu Miyamori
Journal:  Exp Clin Cardiol       Date:  2003
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