Literature DB >> 4066058

Synthesis of 15O-labeled butanol via organoborane chemistry.

G W Kabalka, R M Lambrecht, M Sajjad, J S Fowler, S A Kunda, G W McCollum, R MacGregor.   

Abstract

Oxygen-15 labeled 1-butanol and 2-butanol were prepared by the reaction of O2-15O with tri-n-butylborane and tri-sec-butylborane in tetrahydrofuran. The reaction products were isolated and identified via reversed-phase high performance column chromatography and gas chromatography. Radiochemical yields of 50% (EOB) were obtained. The use of 15O-labeled butanol is suggested for cerebral blood flow measurements in conjunction with PET.

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Year:  1985        PMID: 4066058     DOI: 10.1016/0020-708x(85)90017-1

Source DB:  PubMed          Journal:  Int J Appl Radiat Isot        ISSN: 0020-708X


  2 in total

1.  Effect of partition coefficient, permeability surface product, and radioisotope on the signal-to-noise ratio in PET functional brain mapping: a computer simulation.

Authors:  C C Martin; P A Jerabek; L D Nickerson; P T Fox
Journal:  Hum Brain Mapp       Date:  1999       Impact factor: 5.038

2.  Pharmacokinetics and radiation dose of oxygen-15 labelled butanol in rCBF studies in humans.

Authors:  H Herzog; R J Seitz; L Tellmann; G Schlaug; A Kleinschmidt; B Nebeling; G Stöcklin; H W Müller-Gärtner
Journal:  Eur J Nucl Med       Date:  1994-02
  2 in total

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