| Literature DB >> 4065302 |
J Lyness, A G Robinson, M N Sheridan, D M Gash.
Abstract
The antidiuretic activity of oxytocin (OT) was measured in Brattleboro rats with congenital diabetes insipidus. A dose dependent antidiuretic response was found in animals receiving chronic infusions of 0.1 micrograms/h, 1.0 micrograms/h, and 5 micrograms/h of OT. OT infused at the rate of 5 micrograms/h over a 7-day period completely reversed the symptoms of diabetes insipidus. The results support the concept that OT serves as a weak agonist of vasopressin at the level of the kidney and at pharmacological levels exhibits antidiuretic activity.Entities:
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Year: 1985 PMID： 4065302 DOI： 10.1007/BF01950026
Source DB: PubMed Journal: Experientia ISSN： 0014-4754