Literature DB >> 4065300

Organophosphate-mediated inhibition of choline acetyltransferase activity in rat brain tissue.

T L Thompson, W E Thomas.   

Abstract

Administration of the organophosphate compound soman in rats resulted in an inhibition of choline acetyltransferase activity in almost all brain regions examined. Enzyme activity was inhibited by 20-50% in various brain regions 30 min after soman injection (94-120 micrograms/kg). Enzyme activity in two regions decreased with time to a near zero level by 3 h after injection.

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Year:  1985        PMID： 4065300     DOI： 10.1007/BF01950022

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  Pharmacology of organophosphorus cholinesterase inhibitors.

Authors:  B HOLMSTEDT
Journal:  Pharmacol Rev       Date:  1959-09       Impact factor: 25.468

2.  A rapid radiochemical method for the determination of choline acetyltransferase.

Authors:  F Fonnum
Journal:  J Neurochem       Date:  1975-02       Impact factor: 5.372

3.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

4.  Psychiatric manifestations from insecticide exposure.

Authors:  M S Biskind; R F Mobbs
Journal:  JAMA       Date:  1972-05-29       Impact factor: 56.272

5.  Effect of atropine and/or physostigmine on cerebral acetylcholine in rats poisoned with soman.

Authors:  L W Harris; W C Heyl; D L Stitcher; R D Moore
Journal:  Life Sci       Date:  1978-03       Impact factor: 5.037

6.  Inhibition of rat cerebrum acetylcholinesterase isoenzymes after acute administration of soman.

Authors:  D E Lenz; D M Maxwell
Journal:  Biochem Pharmacol       Date:  1981-06-01       Impact factor: 5.858

7.  Anxiety associated with exposure to organophosphate compounds.

Authors:  H S Levin; R L Rodnitzky; D L Mick
Journal:  Arch Gen Psychiatry       Date:  1976-02

8.  A direct radioisotopic assay for acetylcholinesterase.

Authors:  D J Reed; K Goto; C H Wang
Journal:  Anal Biochem       Date:  1966-07       Impact factor: 3.365

9.  Toxicity of soman after repetitive injection of sublethal doses in guinea-pig and mouse.

Authors:  S H Sterri; S Lyngaas; F Fonnum
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1981-07

10.  Clinical and electrophysiological study of neuropathy after organophosphorus compounds poisoning.

Authors:  C Vasilescu; A Florescu
Journal:  Arch Toxicol       Date:  1980-02       Impact factor: 5.153
  10 in total

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