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Literature DB >> 4065187

Antisecretory effect and oral pharmacokinetics of omeprazole in patients with chronic renal failure.

C W Howden, C D Payton, P A Meredith, D M Hughes, A I Macdougall, J L Reid, J A Forrest.

Abstract

The inhibitory effect of omeprazole on gastric acid secretion was tested in a group of patients on haemodialysis for chronic renal failure. Single 30 mg doses almost totally inhibited basal acid output on both dialysis and non-dialysis days. Plateau acid output was reduced by a mean of 77% and 90% on non-dialysis and dialysis days respectively. The absorption and pharmacokinetic profile of omeprazole were not affected by dialysis. Omeprazole was not recoverable from dialysis fluid. It is concluded that omeprazole is a potent inhibitor of gastric acid secretion in patients with chronic renal failure, and its effect is not influenced by haemodialysis.

Entities: Chemical Disease Species

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Year: 1985 PMID： 4065187 DOI： 10.1007/BF00607907

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

13 in total

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8 in total