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Literature DB >> 40645

The protective effect of some phenothiazine derivatives against streptolysin O.

D Besluau, S Gauthier-Rahman, B Halpern.

Abstract

1 Chlorpromazine (Cpz) and promethazine (Pmz) protected mice against lethal doses of streptolysin O (SLO) given intravenously. Three other phenothiazine derivatives had similar but lesser effects. 2 The protective effect developed slowly; maximal protection was obtained 4 h after subcutaneous injection of Cpz and Pmz. 3 The haemolytic activity of SLO in vitro was also inhibited by Cpz.

Entities: Chemical Species

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Year: 1979 PMID： 40645 PMCID： PMC2043882 DOI： 10.1111/j.1476-5381.1979.tb08663.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

20 in total

1. Studies on the mechanism of the lethal toxic action of streptolysin "O" and the protection by certain antiserotonin drugs.

Authors: S P HALBERT; R BIRCHER; E DAHLE
Journal: J Lab Clin Med Date: 1963-03

2. [Studies on exogenous and endogenous substances acting on capillary permeability and their antagonists].

Authors: B N HALPERN; P LIACOPOULOS; M LIACOPOULOS-BRIOT
Journal: Arch Int Pharmacodyn Ther Date: 1959-03-01

3. The effect of phenothiazine drugs on the removal of cholinesterase from erythrocytes and on hemolysis by lysolecithin.

Authors: M E GREIG; A J GIBBONS
Journal: Arch Biochem Biophys Date: 1956-04 Impact factor: 4.013

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Authors: B N HALPERN; B DREYFUS; G BOURDON
Journal: Presse Med Date: 1950-10-18 Impact factor: 1.228

5. Purification and some properties of streptolysin O.

Authors: J E Alouf; M Raynaud
Journal: Biochimie Date: 1973 Impact factor: 4.079

6. Effects of chlorpromazine on biological membranes-II. Chlorpromazine-induced changes in human erythrocytes.

Authors: A R FREEMAN; M A SPIRTES
Journal: Biochem Pharmacol Date: 1963-01 Impact factor: 5.858

7. Effects of chlorpromazine on biological membranes--I. Chlorpromazine-induced changes in liver mitochondria.

Authors: M A SPIRTES; P S GUTH
Journal: Biochem Pharmacol Date: 1963-01 Impact factor: 5.858

8. The analysis of streptococcal infections. V. Cardiotoxicity of streptolysin O for rabbits in vivo.

Authors: S P HALBERT; R BIRCHER; E DAHLE
Journal: J Exp Med Date: 1961-04-01 Impact factor: 14.307

9. Loss of myocardial contractility induced in isolated mammalian hearts by streptolysin O.

Authors: A W BERNHEIMER; A S CARLSON; E B FREEMAN; A KELLNER
Journal: J Exp Med Date: 1956-09-01 Impact factor: 14.307

10. STUDIES ON LYSOSOMES. III. THE EFFECTS OF STREPTOLYSINS O AND S ON THE RELEASE OF ACID HYDROLASES FROM A GRANULAR FRACTION OF RABBIT LIVER.

Authors: G WEISSMANN; H KEISER; A W BERNHEIMER
Journal: J Exp Med Date: 1963-08-01 Impact factor: 14.307

2 in total

1. In vivo and in vitro studies of bacterial endotoxin-membrane interactions and the effects of membrane-active agents.

Authors: M E Garnett; D V Godin; J M Tuchek
Journal: Br J Pharmacol Date: 1984-09 Impact factor: 8.739

2. Plasma acid phosphatase levels in endotoxaemia: modification by drugs and chemically detoxified endotoxins.

Authors: D V Godin; J M Tuchek
Journal: Br J Pharmacol Date: 1983-06 Impact factor: 8.739

2 in total