| Literature DB >> 406431 |
J J Schentag, W J Jusko, M E Plaut, T J Cumbo, J W Vance, E Abrutyn.
Abstract
A two-compartment pharmcokinetic model was used to caracterize serum concentrations and to predict tissue accumulation of gentamicin in 47 treated patients. Postmortem tissues were obtained in six cases; in each instance, tissues yielded the predicted amount of drug. Slow release of tissue-bound gentamicin accounts for its prolonged retention in the body. The two-compartment model adequately predicts gentamicin accumulation from serum concentrations and explains why this antibiotic persists in serum and urine.Entities:
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Year: 1977 PMID： 406431
Source DB: PubMed Journal: JAMA ISSN： 0098-7484 Impact factor: 56.272