Literature DB >> 4063957

Hypergastrinemia and colorectal carcinogenesis in the rat.

D A Karlin, M McBath, R D Jones, K E Elwyn, M M Romsdahl.   

Abstract

Our objective was to determine whether chronic hypergastrinemia enhances chemical induction of rat colorectal cancers. Forty-five rats were randomized to sham operation or antral exclusion. Following a 2-week postoperative recovery period all rats were treated with 1,2-dimethylhydrazine (10 mg/kg) intraperitoneally for 20 weekly doses. Seven weeks later, the rats were killed. Blood was assayed for gastrin by radioimmunoassay. Tumor number, location, size, weight and histology were determined. The 23 rats receiving antral exclusion were hypergastrinemic compared with the 22 sham operated rats. All hypergastrinemic rats developed tumors while only 72.7% of normogastrinemic rats developed tumors. Hypergastrinemia increased the number of tumors/rat, total tumor weight/rat and total tumor volume/rat.

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Year:  1985        PMID： 4063957     DOI： 10.1016/0304-3835(85)90125-9

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  13 in total

1.  Death from malignant disease after surgery for duodenal ulcer.

Authors:  J R Duncan; J R McGregor; P J O'Dwyer
Journal:  Gut       Date:  1995-03       Impact factor: 23.059

2.  Elevated gastrin levels in patients with colon cancer or adenomatous polyps.

Authors:  J P Smith; J G Wood; T E Solomon
Journal:  Dig Dis Sci       Date:  1989-02       Impact factor: 3.199

3.  Differences in plasma gastrin, CEA, and CA 19-9 concentration in patients with proximal and distal colorectal cancer.

Authors:  Grzegorz Bombski; Anita Gasiorowska; Daria Orszulak-Michalak; Beata Neneman; Justyna Kotynia; Janusz Strzelczyk; Adam Janiak; Ewa Malecka-Panas
Journal:  Int J Gastrointest Cancer       Date:  2002

4.  Plasma levels of progastrin but not amidated gastrin or glycine extended gastrin are elevated in patients with colorectal carcinoma.

Authors:  R K Siddheshwar; J C Gray; S B Kelly
Journal:  Gut       Date:  2001-01       Impact factor: 23.059

5.  P53 gene mutation increases progastrin dependent colonic proliferation and colon cancer formation in mice.

Authors:  Vigneshwaran Ramanathan; Guangchun Jin; Christoph Benedikt Westphalen; Ashley Whelan; Alexander Dubeykovskiy; Shigeo Takaishi; Timothy C Wang
Journal:  Cancer Invest       Date:  2012-04-05       Impact factor: 2.176

Review 6.  The production and role of gastrin-17 and gastrin-17-gly in gastrointestinal cancers.

Authors:  Jeffrey Copps; Richard F Murphy; Sándor Lovas
Journal:  Protein Pept Lett       Date:  2009       Impact factor: 1.890

7.  Progastrin Peptides Increase the Risk of Developing Colonic Tumors: Impact on Colonic Stem Cells.

Authors:  Pomila Singh; Shubhashish Sarkar; Carla Kantara; Carrie Maxwell
Journal:  Curr Colorectal Cancer Rep       Date:  2012-12

8.  Postprandial hypergastrinaemia in patients with colorectal cancer.

Authors:  K Wong; K Beardshall; C M Waters; J Calam; G J Poston
Journal:  Gut       Date:  1991-11       Impact factor: 23.059

Review 9.  Effects of hypochlorhydria and hypergastrinemia on structure and function of gastrointestinal cells. A review and analysis.

Authors:  J W Freston; K Borch; S J Brand; E Carlsson; W Creutzfeldt; R Håkanson; L Olbe; E Solcia; J H Walsh; M M Wolfe
Journal:  Dig Dis Sci       Date:  1995-02       Impact factor: 3.199

10.  Colorectal cancer risk in relation to use of acid suppressive medications.

Authors:  Jessica Chubak; Denise M Boudreau; Stephen J Rulyak; Margaret T Mandelson
Journal:  Pharmacoepidemiol Drug Saf       Date:  2009-07       Impact factor: 2.890
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