| Literature DB >> 406395 |
R A Parker, T Kariya, J M Grisar, V Petrow.
Abstract
5-(Tetradecyloxy)-2-furancarboxylic acid (91, RMI 14514) was found to lower blood lipids and to inhibit fatty acid synthesis with minimal effects on liver weight and liver fat content. This fatty acid-like compound represents a new class of hypolipidemic agent; it is effective in rats and monkeys. The compound resulted from discovery of hypolipidemic activity in certain beta-keto esters, postulation and confirmation of the corresponding benzoic acids as active metabolites, and systematic exploration of the structure--activity relationships.Entities:
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Year: 1977 PMID： 406395 DOI： 10.1021/jm00216a009
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446