Literature DB >> 4061700

Pharmacokinetic interaction of disulfiram and antidepressants.

D A Ciraulo, J Barnhill, H Boxenbaum.   

Abstract

Intravenous imipramine and desipramine were administered to two detoxified alcoholics before and during disulfiram treatment. Tricyclic pharmacokinetic parameters, determined from plasma samples over 48 hours, indicated decreased total body clearance, increased elimination half-life, and higher peak plasma levels during disulfiram treatment.

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Year:  1985        PMID： 4061700     DOI： 10.1176/ajp.142.11.1373

Source DB:  PubMed          Journal:  Am J Psychiatry        ISSN： 0002-953X            Impact factor:   18.112


  5 in total

1.  Impact of ignoring extraction ratio when predicting drug-drug interactions, fraction metabolized, and intestinal first-pass contribution.

Authors:  Brian J Kirby; Jashvant D Unadkat
Journal:  Drug Metab Dispos       Date:  2010-08-19       Impact factor: 3.922

Review 2.  Importance of multi-p450 inhibition in drug-drug interactions: evaluation of incidence, inhibition magnitude, and prediction from in vitro data.

Authors:  Nina Isoherranen; Justin D Lutz; Sophie P Chung; Houda Hachad; Rene H Levy; Isabelle Ragueneau-Majlessi
Journal:  Chem Res Toxicol       Date:  2012-09-27       Impact factor: 3.739

3.  Steady-state plasma levels of clomipramine and its metabolites: impact of the sparteine/debrisoquine oxidation polymorphism. Danish University Antidepressant Group.

Authors:  K K Nielsen; K Brøsen; L F Gram
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

Review 4.  Clinical pharmacokinetics of drugs used to treat urge incontinence.

Authors:  David R P Guay
Journal:  Clin Pharmacokinet       Date:  2003       Impact factor: 6.447

5.  Volume of Distribution is Unaffected by Metabolic Drug-Drug Interactions.

Authors:  Jasleen K Sodhi; Caroline H Huang; Leslie Z Benet
Journal:  Clin Pharmacokinet       Date:  2021-02       Impact factor: 5.577
  5 in total

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