Literature DB >> 4060071

Vitamin A and retinoic acid: induced fibroblast differentiation in vitro.

A A Demetriou, S M Levenson, G Rettura, E Seifter.   

Abstract

The role of vitamin A in wound healing and fibroplasia has been studied extensively in vivo but the mechanism(s) of its action has not been established. In this study the effect of vitamin A and retinoic acid on fibroblast growth and collagen accumulation in vitro was examined. Vitamin A and retinoic acid added to Balb 3T3 mouse fibroblasts in tissue culture resulted in induction of cell differentiation as manifested by a decrease in cell growth rate, enhanced collagen accumulation, and morphologic differentiation. The results of this in vitro study suggest that the stimulatory in vivo effect of vitamin A and retinoic acid on collagen accumulation and fibroplasia in healing wounds is due in a major way to fibroblast differentiation and enhanced collagen synthesis.

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Year:  1985        PMID： 4060071

Source DB:  PubMed          Journal:  Surgery        ISSN： 0039-6060            Impact factor:   3.982


  7 in total

1.  Supplemental vitamin A prevents the tumor-induced defect in wound healing.

Authors:  J Weinzweig; S M Levenson; G Rettura; N Weinzweig; J Mendecki; T H Chang; E Seifter
Journal:  Ann Surg       Date:  1990-03       Impact factor: 12.969

2.  Flexible liposomal gel dual-loaded with all-trans retinoic acid and betamethasone for enhanced therapeutic efficiency of psoriasis.

Authors:  Wei Wang; Gao-Feng Shu; Kong-Jun Lu; Xiao-Ling Xu; Min-Cheng Sun; Jing Qi; Qiao-Ling Huang; Wei-Qiang Tan; Yong-Zhong Du
Journal:  J Nanobiotechnology       Date:  2020-05-24       Impact factor: 10.435

3.  In Vitro Wound Healing Properties of Novel Acidic Treatment Regimen in Enhancing Metabolic Activity and Migration of Skin Cells.

Authors:  Pivian Sim; Yunmei Song; Gink N Yang; Allison J Cowin; Sanjay Garg
Journal:  Int J Mol Sci       Date:  2022-06-28       Impact factor: 6.208

4.  Retinoic acid stimulation of human dermal fibroblast proliferation is dependent on suboptimal extracellular Ca2+ concentration.

Authors:  J Varani; J Shayevitz; D Perry; R S Mitra; B J Nickoloff; J J Voorhees
Journal:  Am J Pathol       Date:  1990-06       Impact factor: 4.307

5.  TGF-beta1 induces bone marrow reticulin fibrosis in hairy cell leukemia.

Authors:  Medhat Shehata; Josef D Schwarzmeier; Martin Hilgarth; Rainer Hubmann; Markus Duechler; Heinz Gisslinger
Journal:  J Clin Invest       Date:  2004-03       Impact factor: 14.808

6.  Effects of all-trans retinoic acid and Ca++ on human skin in organ culture.

Authors:  J Varani; S E Fligiel; L Schuger; P Perone; D Inman; C E Griffiths; J J Voorhees
Journal:  Am J Pathol       Date:  1993-01       Impact factor: 4.307

7.  Triple nanoemulsion potentiates the effects of topical treatments with microencapsulated retinol and modulates biological processes related to skin aging.

Authors:  Alessandro Afornali; Rodrigo de Vecchi; Rodrigo Makowiecky Stuart; Gustavo Dieamant; Luciana Lima de Oliveira; Carla Abdo Brohem; Israel Henrique Stokfisz Feferman; Lincoln Helder Zambaldi Fabrício; Márcio Lorencini
Journal:  An Bras Dermatol       Date:  2013 Nov-Dec       Impact factor: 1.896
  7 in total

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