| Literature DB >> 4058447 |
B Lambert, Y Chen, S M He, M Sten.
Abstract
Human leucocytes were incubated in the presence of vinyl acetate or acetaldehyde (10-20 mM) for 4 h at 37 degrees C in vitro. DNA damage was analysed by alkaline elution. None of the compounds induced a detectable increase in the frequency of DNA strand breaks. Cells exposed to 5 Gy of X-ray immediately after treatment and before alkaline elution showed a clear, dose-dependent retardation of the elution rate in comparison with X-irradiated control cells. These results demonstrate that both vinyl acetate and acetaldehyde induce DNA cross-links in human cells.Entities:
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Year: 1985 PMID： 4058447 DOI： 10.1016/0167-8817(85)90072-0
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433