Literature DB >> 4058100

Immunotoxicity screening of drugs and chemicals: value of contact hypersensitivity to picryl chloride in the mouse.

J Descotes, R Tedone, J C Evreux.   

Abstract

Contact hypersensitivity to picryl chloride in the mouse is proposed as a valuable tool for the in vivo immunotoxicological testing of new compounds. Reproducibility was found to be excellent. Results obtained in the present work with chlorpromazine, cyclophosphamide, diazepam, haloperidol, hydrocortisone, promethazine and lead acetate, nickel chloride and selenium were similar to those previously reported regarding the effects of these compounds on cell-mediated immunity.

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Year:  1985        PMID: 4058100

Source DB:  PubMed          Journal:  Methods Find Exp Clin Pharmacol        ISSN: 0379-0355


  2 in total

1.  Development of a Delayed-Type Hypersensitivity (DTH) Model in the Cynomolgus Monkey.

Authors:  Caroline Bouchez; Fréderic Gervais; Renaud Fleurance; Bernard Palate; Jean-Jacques Legrand; Jacques Descotes
Journal:  J Toxicol Pathol       Date:  2012-06       Impact factor: 1.628

2.  Safety immunopharmacology: evaluation of the adverse potential of pharmaceuticals on the immune system.

Authors:  Jacques Descotes
Journal:  J Pharmacol Toxicol Methods       Date:  2012-05-14       Impact factor: 1.950

  2 in total

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