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Literature DB >> 40549

Precocious development of cytochrome P-450 in neonatal rat liver after glucocorticoid treatment.

Abstract

Intraperitoneal injection of neonatal rats with glucocorticoid hormones causes precocious development of hepatic cytochrome P-450. Glucagon injection fails to stimulate this cytochrome P-450 development. Adult liver cytochrome P-450 is less responsive to glucocorticoid stimulation than is that of neonatal rat liver. Adrenalectomy of prematurely delivered neonatal animals prevents the early postnatal development of cytochrome P-450. Glucocorticoids failed to increase cytochrome P-450 concentrations in foetal rat liver. These findings imply that, although glucocorticoids are mandatory regulatory factors controlling cytochrome P-450 development, they are not themselves the 'trigger' initiating onset of that development.

Entities: Chemical Gene Species

Mesh：

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Year: 1979 PMID： 40549 PMCID： PMC1161253 DOI： 10.1042/bj1820233

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

17 in total

1. THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

Authors: T OMURA; R SATO
Journal: J Biol Chem Date: 1964-07 Impact factor: 5.157

2. Steroids and the maturation of rat tissues.

Authors: O Greengard
Journal: J Steroid Biochem Date: 1975-05 Impact factor: 4.292

3. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

4. Pharmacological implications of microsomal enzyme induction.

Authors: A H Conney
Journal: Pharmacol Rev Date: 1967-09 Impact factor: 25.468

5. Studies on the mechanism of induction of tyrosine aminotransferase in neonatal rat liver.

Authors: P G Holt; I T Oliver
Journal: Biochemistry Date: 1969-04 Impact factor: 3.162

6. Regulation of onset of development of UDP-glucuronosyltransferase activity towards o-aminophenol by glucocorticoids in late-foetal rat liver in utero.

Authors: G J Wishart; G J Dutton
Journal: Biochem J Date: 1977-12-15 Impact factor: 3.857

7. Precocious induction of hepatic aniline hydroxylase and aminopyrine N-demethylase with hydrocortisone in neonatal rat.

Authors: H Mukhtar; M K Sahib; J R Kidwai
Journal: Biochem Pharmacol Date: 1974-01-15 Impact factor: 5.858

8. The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states.

Authors: D W Nebert; H V Gelboin
Journal: Arch Biochem Biophys Date: 1969-10 Impact factor: 4.013

9. The hormonal regulation of enzymes in penatal and postnatal rat liver. Effects of adenosine 3',5'-(cyclic)-monophosphate.

Authors: O Greengard
Journal: Biochem J Date: 1969-10 Impact factor: 3.857

Review 5. Drug metabolism by the human fetus.

Authors: M R Juchau; S T Chao; C J Omiecinski
Journal: Clin Pharmacokinet Date: 1980 Jul-Aug Impact factor: 6.447

5 in total

Precocious development of cytochrome P-450 in neonatal rat liver after glucocorticoid treatment.

1. THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

2. Steroids and the maturation of rat tissues.

3. Protein measurement with the Folin phenol reagent.

4. Pharmacological implications of microsomal enzyme induction.

5. Studies on the mechanism of induction of tyrosine aminotransferase in neonatal rat liver.

6. Regulation of onset of development of UDP-glucuronosyltransferase activity towards o-aminophenol by glucocorticoids in late-foetal rat liver in utero.

7. Precocious induction of hepatic aniline hydroxylase and aminopyrine N-demethylase with hydrocortisone in neonatal rat.

8. The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states.

9. The hormonal regulation of enzymes in penatal and postnatal rat liver. Effects of adenosine 3',5'-(cyclic)-monophosphate.

10. Effect of development on the activity of microsomal drug-metabolizing enzymes in rat liver.

1. Refining the critical period for methamphetamine-induced spatial deficits in the Morris water maze.

2. Budesonide effects on Clara cell under normal and allergic inflammatory condition.

3. Modulation of functional activities in cultured rat hepatocytes.

4. Environmental influences on human foetal and placental xenobiotic metabolism.

Review 5. Drug metabolism by the human fetus.