Literature DB >> 4054209

Pharmacokinetics of triamcinolone acetonide and its phosphate ester.

H Möllmann, P Rohdewald, E W Schmidt, V Salomon, H Derendorf.   

Abstract

Triamcinolone acetonide in the form of its phosphate ester was given intravenously in two different doses (10 mg/kg and 80 mg). Plasma levels of the ester and triamcinolone acetonide were measured and pharmacokinetic parameters were calculated. The pharmacokinetics both of the phosphate and the free alcohol were dose-dependent. No unchanged ester was found in the urine, indicating complete conversion of the pro-drug. Triamcinolone was not a major metabolite of triamcinolone acetonide in humans. Renal clearance was low and independent of the dose. Only about 1% of the dose was found in the urine as triamcinolone acetonide.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 4054209     DOI： 10.1007/BF00547374

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  8 in total

1.  Comparative studies on absorption and metabolic disposal of water-soluble corticosteroid esters.

Authors:  J C MELBY; M ST CYR
Journal:  Metabolism       Date:  1961-01       Impact factor: 8.694

2.  [Course of plasma- and urine level after intramuscular application of 40, 80 and 120 mg of triamcinolone-acetonide].

Authors:  L Zicha
Journal:  Arzneimittelforschung       Date:  1969-03

3.  ESTRIP, a BASIC computer program for obtaining initial polyexponential parameter estimates.

Authors:  R D Brown; J E Manno
Journal:  J Pharm Sci       Date:  1978-12       Impact factor: 3.534

4.  HPLC determination of glucocorticoid alcohols, their phosphates and hydrocortisone in aqueous solutions and biological fluids.

Authors:  H Derendorf; P Rohdewald; G Hochhaus; H Möllmann
Journal:  J Pharm Biomed Anal       Date:  1986       Impact factor: 3.935

5.  Metabolism of triamcinolone acetonide-21-phosphate in dogs, monkeys, and rats.

Authors:  K J Kripalani; A I Cohen; I Weliky; E C Schreiber
Journal:  J Pharm Sci       Date:  1975-08       Impact factor: 3.534

6.  Pharmacokinetics of prednisolone after high doses of prednisolone hemisuccinate.

Authors:  H Derendorf; P Rohdewald; H Möllmann; J Rehder; J Barth; D Neveling
Journal:  Biopharm Drug Dispos       Date:  1985 Oct-Dec       Impact factor: 1.627

7.  Kinetics of methylprednisolone and its hemisuccinate ester.

Authors:  H Derendorf; H Möllmann; P Rohdewald; J Rehder; E W Schmidt
Journal:  Clin Pharmacol Ther       Date:  1985-05       Impact factor: 6.875

8.  [Radioimmunologic detection of triamcinolone-acetonide and its application in a study on the hydrolysis of water soluble corticoid esters].

Authors:  D Haack; P Vecsei
Journal:  Arzneimittelforschung       Date:  1982
  8 in total
  10 in total

1.  Pharmacokinetics and systemic activity of fluticasone via Diskus and pMDI, and of budesonide via Turbuhaler.

Authors:  L Thorsson; S Edsbäcker; A Källén; C G Löfdahl
Journal:  Br J Clin Pharmacol       Date:  2001-11       Impact factor: 4.335

2.  Triamcinolone acetonide: a new management of noncompliance in nephrotic children.

Authors:  Tim Ulinski; Anne Carlier-Legris; Déborah Schlecht; Bruno Ranchin; Pierre Cochat
Journal:  Pediatr Nephrol       Date:  2005-04-21       Impact factor: 3.714

Review 3.  Safety of inhaled and intranasal corticosteroids: lessons for the new millennium.

Authors:  B J Lipworth; C M Jackson
Journal:  Drug Saf       Date:  2000-07       Impact factor: 5.606

4.  Pulmonary targeting of liposomal triamcinolone acetonide phosphate.

Authors:  R J Gonzalez-Rothi; S Suarez; G Hochhaus; H Schreier; A Lukyanov; H Derendorf; T D Costa
Journal:  Pharm Res       Date:  1996-11       Impact factor: 4.200

5.  Phosphoryloxymethyl carbamates and carbonates--novel water-soluble prodrugs for amines and hindered alcohols.

Authors:  M Safadi; R Oliyai; V J Stella
Journal:  Pharm Res       Date:  1993-09       Impact factor: 4.200

6.  The in vitro enzymic labilities of chemically distinct phosphomonoester prodrugs.

Authors:  A S Kearney; V J Stella
Journal:  Pharm Res       Date:  1992-04       Impact factor: 4.200

7.  Synthesis and structure-activity relationships of novel ecdysteroid dioxolanes as MDR modulators in cancer.

Authors:  Ana Martins; József Csábi; Attila Balázs; Diána Kitka; Leonard Amaral; József Molnár; András Simon; Gábor Tóth; Attila Hunyadi
Journal:  Molecules       Date:  2013-12-10       Impact factor: 4.411

8.  Can intramuscular corticosteroid injection cause nonarteritic anterior ischemic optic neuropathy?

Authors:  Berker Bakbak; Banu Turgut Ozturk; Sansal Gedik; Bengu Ekinci Koktekir; Saban Gonul
Journal:  Clin Ophthalmol       Date:  2013-03-26

9.  Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts.

Authors:  Satish Patil; Lev G Lis; Robert J Schumacher; Beverly J Norris; Monique L Morgan; Rebecca A D Cuellar; Bruce R Blazar; Raj Suryanarayanan; Vadim J Gurvich; Gunda I Georg
Journal:  J Med Chem       Date:  2015-11-24       Impact factor: 7.446

10.  Serum Triamcinolone Levels following Cervical Interlaminar Epidural Injection.

Authors:  Tim J Lamer; Rozalin R Dickson; Halena M Gazelka; Wayne T Nicholson; Joel M Reid; Susan M Moeschler; W Michael Hooten
Journal:  Pain Res Manag       Date:  2018-03-21       Impact factor: 3.037
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.