| Literature DB >> 4054110 |
F Lottspeich, J Kellermann, A Henschen, B Foertsch, W Müller-Esterl.
Abstract
The complete amino acid sequence of the light chain of human high-molecular-mass kininogen has been determined. The peptide chain contains 255 amino acid residues. The half-cystine, which forms the disulfide bridge to the heavy chain, was identified in position 225. Nine carbohydrate attachment sites were found. All carbohydrate side chains are O-glycosidically linked. Alignment of the present sequence with the bovine kininogen light chain sequence shows a high degree of homology, except for an extension of 22 amino acids within the histidine-rich part of the sequence. The histidine-rich region may have arisen by gene multiplication during evolution.Entities:
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Year: 1985 PMID： 4054110 DOI： 10.1111/j.1432-1033.1985.tb09199.x
Source DB: PubMed Journal: Eur J Biochem ISSN： 0014-2956