Literature DB >> 4053564

Cartilage collagen analysis in the chondrodystrophies.

W A Horton, J W Chou, M A Machado.   

Abstract

A simple and reproducible method for analyzing small samples of cartilage collagens was developed. Following extraction with guanidine HCl, the cartilage specimens were digested directly with CNBr and the resultant peptides separated by gel-permeation high-performance liquid chromatography. Resting cartilage collagen CNBr peptide maps differed from normal in two inherited chondrodystrophies, achondrogenesis II and spondyloepiphyseal dysplasia congenita.

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Year:  1985        PMID: 4053564     DOI: 10.1016/s0174-173x(85)80023-6

Source DB:  PubMed          Journal:  Coll Relat Res        ISSN: 0174-173X


  3 in total

1.  Mild spondyloepiphyseal dysplasia (Namaqualand type): genetic linkage to the type II collagen gene COL2A1.

Authors:  C Sher; R Ramesar; R Martell; I Learmonth; P Tsipouras; P Beighton
Journal:  Am J Hum Genet       Date:  1991-03       Impact factor: 11.025

2.  Structural and segregation analysis of the type II collagen gene (COL2A1) in some heritable chondrodysplasias.

Authors:  P Wordsworth; D Ogilvie; L Priestley; R Smith; R Wynne-Davies; B Sykes
Journal:  J Med Genet       Date:  1988-08       Impact factor: 6.318

3.  Type II achondrogenesis-hypochondrogenesis: identification of abnormal type II collagen.

Authors:  M Godfrey; D W Hollister
Journal:  Am J Hum Genet       Date:  1988-12       Impact factor: 11.025

  3 in total

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