Literature DB >> 4052731

Effects of pinaverium bromide and verapamil on the motility of the rat isolated colon.

A Baumgartner, E Drack, F Halter, U Scheurer.   

Abstract

Pinaverium bromide was 30 times less potent than verapamil in inhibiting intraluminal pressure responses of in vitro rat colonic segments to barium chloride, acetylcholine, FK 33-824 or field stimulation. The inhibitory effects of both verapamil and pinaverium bromide on the pressure responses to field stimulation were antagonized similarly by exogenous calcium administration. These results support the concept that pinaverium bromide acts on calcium channels in the smooth muscle cell membrane.

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Year:  1985        PMID： 4052731      PMCID： PMC1916849          DOI： 10.1111/j.1476-5381.1985.tb09438.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  7 in total

1.  [Pharmacodynamic study of the spasmolytic properties of pinaverium bromide].

Authors:  J Bretaudeau; O Foussard-Blanpin; R Baronnet; R Desprairies
Journal:  Therapie       Date:  1975 Nov-Dec       Impact factor: 2.070

2.  [Pinaverium bromide and functional colonic disease (double-blind study].

Authors:  C Levy; A Charbonnier; M Cachin
Journal:  Sem Hop Ther       Date:  1977 Sep-Oct

3.  Properties of single calcium channels in cardiac cell culture.

Authors:  H Reuter; C F Stevens; R W Tsien; G Yellen
Journal:  Nature       Date:  1982-06-10       Impact factor: 49.962

4.  Effect of pinaverium bromide on electrical and mechanical activity of smooth muscle cells.

Authors:  G Droogmans; B Himpens; R Casteels
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-06       Impact factor: 3.000

5.  [The value of adding an antispasmodic musculotropic agent in the treatment of painful constipation in functional colopathies with bran. Double-blind study].

Authors:  J Delmont
Journal:  Med Chir Dig       Date:  1981

6.  Inhibitory effect of pinaverium bromide on gastrointestinal contractile activity in conscious dogs.

Authors:  Z Itoh; I Takahashi
Journal:  Arzneimittelforschung       Date:  1981

7.  Morphine-like action of enkephalin analog FK 33-824 on motility of the isolated rat colon.

Authors:  U Scheurer; E Drack; L Varga; F Halter
Journal:  J Pharmacol Exp Ther       Date:  1981-11       Impact factor: 4.030
  7 in total
  7 in total

1.  Effects of pinaverium on voltage-activated calcium channel currents of single smooth muscle cells isolated from the longitudinal muscle of the rabbit jejunum.

Authors:  D J Beech; I MacKenzie; T B Bolton; M O Christen
Journal:  Br J Pharmacol       Date:  1990-02       Impact factor: 8.739

2.  Effects of calcium channel blockers on gastric emptying and acid secretion of the rat in vivo.

Authors:  R Brage; J Cortijo; J Esplugues; J V Esplugues; E Martí-Bonmatí; C Rodriguez
Journal:  Br J Pharmacol       Date:  1986-12       Impact factor: 8.739

Review 3.  Role of antispasmodics in the treatment of irritable bowel syndrome.

Authors:  Anita Annaházi; Richárd Róka; András Rosztóczy; Tibor Wittmann
Journal:  World J Gastroenterol       Date:  2014-05-28       Impact factor: 5.742

4.  Role of L-type calcium channels on yohimbine-precipitated clonidine withdrawal in vivo and in vitro.

Authors:  M Barrios; I Robles; J M Baeyens
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-12       Impact factor: 3.000

5.  Interaction of pinaverium (a quaternary ammonium compound) with 1,4-dihydropyridine binding sites in rat ileum smooth muscle.

Authors:  O Feron; M Wibo; M O Christen; T Godfraind
Journal:  Br J Pharmacol       Date:  1992-02       Impact factor: 8.739

Review 6.  Antispasmodics for Chronic Abdominal Pain: Analysis of North American Treatment Options.

Authors:  Darren M Brenner; Brian E Lacy
Journal:  Am J Gastroenterol       Date:  2021-08-01       Impact factor: 12.045

7.  Assessing the post-treatment therapeutic effect of pinaverium in irritable bowel syndrome: a randomized controlled trial.

Authors:  Liang Zheng; Weimin Lu; Qi Xiao; Yaoliang Lai; Heng Fan; Yuling Sun; Dawei Huang; Yuanyuan Wang; Zhen Li; Zhengyan Jiang; Xingxing Liu; Lijuan Zhang; Dongmei Zuo; Zhexing Shou; Qing Tang; Huisuo Huang; Yongqiang Yang; Zongxiang Tang; Jun Xiao
Journal:  Sci Rep       Date:  2021-07-06       Impact factor: 4.379
  7 in total

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